Olthof Allard W, Sijens Paul E, Kreeftenberg Herman G, Kappert Peter, van der Jagt Eric J, Oudkerk Matthijs
Department of Radiology, Bethesda Hospital, Dr.G.H. Amshoffweg 1, Hoogeveen 7909 AA, The Netherlands.
Eur J Radiol. 2009 Jul;71(1):116-21. doi: 10.1016/j.ejrad.2008.02.008. Epub 2008 Mar 20.
In the non-invasive determination of the liver iron concentration several validated MRI methods are available, two of which are compared in this study. Twenty-eight patients were examined by MRI and evaluated by the methods of Kreeftenberg et al. [Kreeftenberg Jr HG, Mooyaart EL, Huizenga JR, Sluiter WJ, Kreeftenberg Sr HG. Quantification of liver iron concentration with magnetic resonance imaging by combining T1-, T2-weighted spin echo sequences and a gradient echo sequence. Neth J Med 2000;56:133-7] and Gandon et al. [Gandon Y, Olivie D, Guyader D, et al. Non-invasive assessment of hepatic iron stores by MRI. Lancet 2004;363:357-62]. It is concluded that the latter shows a better inter- and intra-observer correlation and is more accurate because of the automated preselection of one of five sequences most sensitive in the estimated liver iron concentration range. In the Kreeftenberg method combining the results of three suboptimal sequences, leads to underestimation of the liver iron concentration.
在肝脏铁浓度的非侵入性测定中，有几种经过验证的MRI方法可供使用，本研究对其中两种方法进行了比较。28名患者接受了MRI检查，并采用Kreeftenberg等人[Kreeftenberg Jr HG, Mooyaart EL, Huizenga JR, Sluiter WJ, Kreeftenberg Sr HG. 通过结合T1、T2加权自旋回波序列和梯度回波序列，利用磁共振成像对肝脏铁浓度进行定量分析。《荷兰医学杂志》2000年；56:133 - 7]以及Gandon等人[Gandon Y, Olivie D, Guyader D, 等。通过MRI对肝脏铁储存进行非侵入性评估。《柳叶刀》2004年；363:357 - 62]的方法进行评估。得出的结论是，后者在观察者间和观察者内显示出更好的相关性，并且由于在估计的肝脏铁浓度范围内自动预选了五个最敏感序列之一，所以更准确。在Kreeftenberg方法中，结合三个次优序列的结果会导致肝脏铁浓度的低估。
