O'Dea Kerin, Cunningham Joan, Maple-Brown Louise, Weeramanthri Tarun, Shaw Jonathan, Dunbar Terry, Zimmet Paul
Department of Medicine (University of Melbourne), St. Vincent's Hospital, Fitzroy, VIC 3065, Australia.
Diabetes Res Clin Pract. 2008 Jun;80(3):483-9. doi: 10.1016/j.diabres.2008.02.008. Epub 2008 Mar 24.
Little is known about the burden of diabetes and related conditions among urban Indigenous Australians. The DRUID study was established to address this important information gap.
Eligible participants were Aboriginal and Torres Strait Islander adult volunteers aged 15 years and over who had lived in a defined region in and around Darwin, NT for at least 6 months.
Participants underwent a health examination based on the AusDiab protocol, including blood and urine collection, clinical and anthropometric measurements and questionnaires, in 2003-2005.
Among 861 participants included in the analysis (approximately 14% of the target population), diabetes and other cardiovascular risk factors were common and increased with age. Almost one-third of those aged >or=35 years (31.7%) and over half of those >or=55 years (52.4%) had diabetes. Of 48 participants with newly diagnosed diabetes, half would not have been diagnosed without OGTT. Cardiovascular risk factors were common even among young people without diabetes-45% had >or=2 risk factors and only 18% had none.
This study indicates a very high burden of current disease and high risk of future disease, even among young people. Both primary prevention and better management of known risk factors and existing disease are urgently required.
对于澳大利亚城市原住民中糖尿病及相关疾病的负担，人们了解甚少。DRUID研究旨在填补这一重要的信息空白。
符合条件的参与者为年龄在15岁及以上、居住在北领地达尔文市及其周边特定区域至少6个月的原住民及托雷斯海峡岛民成年志愿者。
2003年至2005年期间，参与者依据澳大利亚糖尿病研究方案接受了健康检查，包括血液和尿液采集、临床及人体测量以及问卷调查。
纳入分析的861名参与者（约占目标人群的14%）中，糖尿病及其他心血管危险因素普遍存在且随年龄增长而增加。年龄≥35岁的人群中近三分之一（31.7%）以及年龄≥55岁的人群中超过一半（52.4%）患有糖尿病。在48名新诊断出糖尿病的参与者中，若不进行口服葡萄糖耐量试验（OGTT），半数患者将无法被诊断出来。即使在无糖尿病的年轻人中，心血管危险因素也很常见——45%的人有≥2种危险因素，只有18%的人没有任何危险因素。
本研究表明，即使在年轻人中，当前疾病负担也非常高，未来患病风险也很高。迫切需要进行一级预防，并更好地管理已知危险因素和现有疾病。
