Oregon Health Sciences University Portland OR, USA.
Ther Clin Risk Manag. 2006 Sep;2(3):251-8. doi: 10.2147/tcrm.2006.2.3.251.
Mucositis pain is a major clinical problem associated with cancer treatment. Mucosal tissue injury is a dose-limiting side effect and also limits nutritional intake and oral function, resulting in weight loss and nutritional deficits for many patients. The pathophysiology of mucositis is thought to be a complex array of cytokine-mediated events, which begins with mucosal atrophy and eventually leads to the painful ulceration of the mucosa. This article reviews current research related to pain management for mucositis. Effective treatment for mucositis pain must be targeted at the various factors involved in the pain experience. Although a number of interventions aimed to prevent and treat mucositis have been studied, there is little evidence to recommend any one treatment modality. While current strategies for pain management rely on general treatment for acute pain, research developments are aimed at targeting the specific receptors and enzymes involved in mucositis. As these breakthroughs become available clinically, thorough assessment and timely directed interventions must be implemented in order to limit patient distress from mucositis. This article presents an assessment tool specific to mucositis pain, including physical, functional, and pain parameters.
黏膜炎疼痛是与癌症治疗相关的一个主要临床问题。黏膜组织损伤是一个剂量限制的副作用，也限制了营养摄入和口腔功能，导致许多患者体重减轻和营养不足。黏膜炎的病理生理学被认为是一系列复杂的细胞因子介导的事件，它始于黏膜萎缩，最终导致黏膜的疼痛性溃疡。本文综述了与黏膜炎疼痛管理相关的当前研究。有效的黏膜炎疼痛治疗必须针对疼痛体验中涉及的各种因素。尽管已经研究了许多旨在预防和治疗黏膜炎的干预措施，但几乎没有证据推荐任何一种治疗方法。虽然目前的疼痛管理策略依赖于急性疼痛的一般治疗，但研究进展旨在针对参与黏膜炎的特定受体和酶。随着这些突破在临床上的应用，必须进行彻底的评估和及时的针对性干预，以限制患者因黏膜炎而感到的痛苦。本文介绍了一种专门针对黏膜炎疼痛的评估工具，包括身体、功能和疼痛参数。
