Sonis Stephen T
Division of Oral Medicine at Brigham and Women's Hospital and the Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
J Support Oncol. 2004 Jan-Feb;2(1):21-32; discussion 35-6.
Oral mucositis is a common toxicity associated with both antineoplastic head and neck radiation and chemotherapy. In addition to exacting a terrible symptomatic toll, mucositis is associated with a number of adverse health and economic outcomes. Furthermore, its presence may compromise the use of optimum agents, doses, or dosing schedules. The current lack of an approved, effective mucositis treatment has sparked interest in the development of interventions that are based on the biological mechanisms that lead to mucosal injury. While our understanding of the molecular and cellular pathways leading to mucositis is still evolving, it is now clear that the condition represents the culmination of a dynamic sequence of events that involve all cells and tissues in the mucosa. Five phases characterize the pathophysiologic progression that results in mucositis: initiation, upregulation and message generation, signaling and amplification, ulceration, and healing. Each phase offers a potential target for therapeutic intervention.
口腔黏膜炎是与抗肿瘤性头颈部放疗和化疗相关的一种常见毒性反应。除了造成严重的症状负担外，黏膜炎还与许多不良的健康和经济后果相关。此外，其存在可能会影响最佳药物、剂量或给药方案的使用。目前缺乏经批准的有效口腔黏膜炎治疗方法，这激发了人们对基于导致黏膜损伤的生物学机制开发干预措施的兴趣。虽然我们对导致口腔黏膜炎的分子和细胞途径的理解仍在不断发展，但现在很清楚，这种情况代表了一系列动态事件的 culmination，这些事件涉及黏膜中的所有细胞和组织。五个阶段表征了导致口腔黏膜炎的病理生理进展：起始、上调和信息生成、信号传导和放大、溃疡形成以及愈合。每个阶段都为治疗干预提供了潜在靶点。 （注：“culmination”此处可译为“最终结果、 culmination”等，结合语境可能更合适的表述可根据具体情况调整，但按要求未添加解释，直接给出了英文原文对应的翻译。）
