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[拉丁美洲5个城市慢性阻塞性肺疾病的治疗:PLATINO研究]

[Treatment of chronic obstructive pulmonary disease in 5 Latin American cities: the PLATINO study].

作者信息

López Varela María Victorina, Muiño Adriana, Pérez Padilla Rogelio, Jardim José Roberto, Tálamo Carlos, Montes de Oca María, Valdivia Gonzalo, Pertuzé Julio, Halbert Ron, Menezes Ana María

机构信息

Facultad de Medicina, Universidad de la República, Montevideo, Uruguay.

出版信息

Arch Bronconeumol. 2008 Feb;44(2):58-64. doi: 10.1016/s1579-2129(08)60016-6.

Abstract

OBJECTIVE

PLATINO project is a population-based study designed to determine the prevalence of chronic obstructive pulmonary disease (COPD) in São Paulo, Brazil; Mexico City, Mexico; Montevideo, Uruguay; Santiago de Chile, Chile; and Caracas, Venezuela. The objective of this portion of PLATINO was to describe preventive and pharmacological treatment of COPD patients and factors associated with such treatment.

PATIENTS AND METHODS

Eligible subjects completed a questionnaire and underwent postbronchodilator spirometry.

RESULTS

Of the total of 5529 individuals who answered items referring to treatment, 758 had COPD (ratio of postbronchodilator forced expiratory volume in 1 second to forced vital capacity of <0.7), and 86 of them had been previously diagnosed by a physician. Among all COPD patients, only half of smokers or former smokers had been advised to quit and 24.7% had received some type of respiratory medication. Only 13.5% had used inhaled corticosteroids, and those were the patients with the most severe disease. In the group of patients who had a previous medical diagnosis of COPD, 69% of the smokers or former smokers had been advised to quit by a physician and 75.6% had received respiratory medication in the preceding year: 43% reported having used inhaled medication and 36% had used bronchodilators. Rates of vaccination against influenza and the use of mucolytic drugs and inhalers varied from one health care facility to another. All drug prescriptions were based on previous spirometry.

CONCLUSIONS

Spirometry emerged not only as a diagnostic tool, but also as a factor associated with treatment, against a background of uneven use of available health care resources in these 5 Latin American cities.

摘要

目的

PLATINO项目是一项基于人群的研究,旨在确定巴西圣保罗、墨西哥墨西哥城、乌拉圭蒙得维的亚、智利圣地亚哥和委内瑞拉加拉加斯慢性阻塞性肺疾病(COPD)的患病率。PLATINO项目这一部分的目的是描述COPD患者的预防和药物治疗以及与此类治疗相关的因素。

患者与方法

符合条件的受试者完成一份问卷并接受支气管扩张剂后肺功能测定。

结果

在总共5529名回答了有关治疗问题的个体中,758人患有COPD(支气管扩张剂后1秒用力呼气量与用力肺活量之比<0.7),其中86人此前已由医生诊断。在所有COPD患者中,只有一半的吸烟者或既往吸烟者被建议戒烟,24.7%的患者接受过某种类型的呼吸药物治疗。只有13.5%的患者使用过吸入性糖皮质激素,且这些患者病情最为严重。在先前有COPD医学诊断的患者组中,69%的吸烟者或既往吸烟者已被医生建议戒烟,75.6%的患者在上一年接受过呼吸药物治疗:43%的患者报告使用过吸入药物,36%的患者使用过支气管扩张剂。流感疫苗接种率以及黏液溶解剂和吸入器的使用情况在不同医疗机构之间存在差异。所有药物处方均基于先前的肺功能测定结果。

结论

在这5个拉丁美洲城市,可用医疗资源使用不均衡的背景下,肺功能测定不仅成为一种诊断工具,而且成为与治疗相关的一个因素。

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