Zengi Ayhan, Karadeniz Muammer, Erdogan Mehmet, Ozgen Ahmet Gökhan, Saygili Fusun, Yilmaz Candeger, Kabalak Taylan
Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Ege, Izmir, Turkey.
Endocr J. 2008 May;55(2):325-30. doi: 10.1507/endocrj.k08e-007. Epub 2008 Mar 25.
Besides the genetic and environmental factors, radiation is an important aetiological cause in the occurrence of thyroid cancer (TC), particularly papillary carcinoma. Chernobyl disaster led to a dramatic increase in the frequency of TC in Eastern Europe. We aimed to determine the data of TC in our unit from 1982 to 2006 and whether Chernobyl disaster has a possible effect on TC distribution. The data of 351 patients with TC are reviewed retrospectively. The dates at diagnosis were classified in five time periods. The ratios of TCs in our unit were concordant with the literature. Comparing the five 5-year periods, there was a significant decrease in the ratio of follicular carcinoma (p<0.01) although the ratio of other thyroid cancers did not change (p>0.05). The ratio of papillary microcarcinoma increased (p<0.01) while the ratio of classical form decreased (p<0.01). The differences between the time periods and the mean ages at diagnosis for each TCs were not significant (p>0.05). If Chernobyl disaster had any effect, the mean age at diagnosis would be younger. The decrease in the ratio of follicular carcinoma in our study may be due to iodine supplementation. The higher ratio of papillary microcarcinoma can be related to increased diagnostic scrutiny. Epidemiological studies are necessary to determine TC incidence in Turkey.
除遗传和环境因素外，辐射是甲状腺癌（TC）尤其是乳头状癌发生的重要病因。切尔诺贝利灾难导致东欧甲状腺癌发病率急剧上升。我们旨在确定1982年至2006年我们科室甲状腺癌的数据，以及切尔诺贝利灾难是否对甲状腺癌的分布有潜在影响。对351例甲状腺癌患者的数据进行回顾性分析。诊断日期分为五个时间段。我们科室甲状腺癌的比例与文献一致。比较五个5年时间段，滤泡癌的比例显著下降（p<0.01），而其他甲状腺癌的比例没有变化（p>0.05）。乳头状微小癌的比例增加（p<0.01），而经典型的比例下降（p<0.01）。各时间段之间以及每种甲状腺癌诊断时的平均年龄差异均无统计学意义（p>0.05）。如果切尔诺贝利灾难有任何影响，诊断时的平均年龄会更年轻。我们研究中滤泡癌比例的下降可能归因于碘补充。乳头状微小癌比例较高可能与诊断检查增加有关。有必要开展流行病学研究以确定土耳其的甲状腺癌发病率。
