以N-甲基吡咯烷酮为通用溶剂，通过VNSAr-SN反应一锅法合成杂芳基化芳基乙酸酯。
One-pot three component synthesis of heteroarylated arylacetates via VNSAr-SN reaction using N-methylpyrrolidone as general solvent.
作者信息
Cao Song, Wu Jingjing, Li Lina, Zhu Longjie, Zhang Jian, Yu Jinlong, Qian Xuhong
机构信息
Shanghai Key Laboratory of Chemical Biology, Center of Fluorine Chemical Technology, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, China.
出版信息
Org Biomol Chem. 2008 Apr 7;6(7):1293-7. doi: 10.1039/b719185e. Epub 2008 Feb 27.
DOI:10.1039/b719185e
PMID:18362971
Abstract
An efficient three component one-pot method was developed to assemble 2-heteroaryl-2-aryl acetates via VNS(Ar)-S(N)Ar and VNS(Ar)-S(N) reaction by using N-methylpyrrolidone (NMP) as general solvent.
摘要
开发了一种高效的三组分一锅法，通过VNS(Ar)-S(N)Ar和VNS(Ar)-S(N)反应，以N-甲基吡咯烷酮（NMP）作为通用溶剂来组装2-杂芳基-2-芳基乙酸酯。
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