Schechner R, Gdal-on M, Cohen D, Meyer E, Zonis S, Perlman I
Invest Ophthalmol Vis Sci. 1987 Sep;28(9):1605-13.
Argon laser is widely used to coagulate the diabetic retina in order to inhibit the proliferative stage of diabetic retinopathy. Ten pigmented rabbits underwent retinal photocoagulation with argon laser. Retinal function was assessed electroretinographically before treatment and at different time intervals after treatment. The ERG responses measured 4-7 days after treatment were reduced in amplitude by a degree which was proportional to the number of laser applications. In five eyes that were treated with at least 1000 applications the ERG responses were very small when measured 4 days post-treatment. However, a gradual recovery was observed and within 2 months the ERG responses approached the normal pretreatment amplitudes. Histological findings from light and electron-microscopy suggested that the ERG recovery could not be solely explained by healing of the coagulated areas. Structural differences were seen in the pigment epithelial layer between a retina obtained immediately after treatment and one studied after ERG recovery. It is suggested that changes in the electrical resistance of the pigment epithelium may contribute to the ERG reduction seen immediately after laser treatment in the rabbit and to the increase in the ERG amplitude observed during the apparent functional recovery of the retina.
氩激光被广泛用于凝固糖尿病患者的视网膜，以抑制糖尿病视网膜病变的增殖期。十只色素沉着的兔子接受了氩激光视网膜光凝治疗。在治疗前和治疗后的不同时间间隔通过视网膜电图评估视网膜功能。治疗后4 - 7天测量的视网膜电图反应幅度降低，降低程度与激光照射次数成正比。在至少接受1000次照射的五只眼睛中，治疗后4天测量时视网膜电图反应非常小。然而，观察到反应逐渐恢复，在2个月内视网膜电图反应接近治疗前的正常幅度。光镜和电镜的组织学结果表明，视网膜电图的恢复不能仅仅用凝固区域的愈合来解释。在治疗后立即获得的视网膜与视网膜电图恢复后研究的视网膜之间，色素上皮层存在结构差异。有人认为，色素上皮电阻的变化可能导致兔子激光治疗后立即出现的视网膜电图降低，以及在视网膜明显功能恢复期间观察到的视网膜电图幅度增加。
