Lôo H, Malka R, Defrance R, Barrucand D, Benard J Y, Niox-Rivière H, Raab A, Sarda A, Vachonfrance G, Kamoun A
Service Hospitalo-Universitaire de Santé mentale et thérapeutique, Hôpital Sainte-Anne, Paris, France.
Neuropsychobiology. 1988;19(2):79-85. doi: 10.1159/000118439.
129 chronic alcoholic patients, withdrawn from alcohol and presenting major depression or dysthymic disorder, were treated for 4-8 weeks under double-blind conditions either with a new antidepressant, tianeptine (37.5 mg per day), or with amitriptyline (75 mg per day). Both groups presented steady improvement of the symptoms of depression during treatment, as scored on the Montgomery and Asberg Depression Rating Scale and the Hopkins Symptom Checklist self-evaluation; for the latter scale, the improvement was significantly greater in the tianeptine group. In addition to the improvement of mood, tianeptine also produced significant reduction of the somatic complaints of the depressed patients. Furthermore, tianeptine possesses anxiolytic activity, as shown by the change of the Hamilton Anxiety Rating Scale global score, similar to that produced by amitriptyline. The anxiolytic activity of tianeptine was not accompanied by any impairment of vigilance, unlike that of amitriptyline. Tianeptine produced rare, mild anticholinergic effects. The results obtained show that tianeptine is an effective anxiolytic antidepressant, with better safety than amitriptyline, suitable for use in the treatment of mood disorders following alcohol withdrawal.
129名慢性酒精中毒患者，戒酒且患有重度抑郁症或心境恶劣障碍，在双盲条件下接受了4至8周的治疗，一组服用新型抗抑郁药噻奈普汀（每天37.5毫克），另一组服用阿米替林（每天75毫克）。根据蒙哥马利和阿斯伯格抑郁评定量表以及霍普金斯症状清单自评得分，两组在治疗期间抑郁症状均稳步改善；对于后者量表，噻奈普汀组的改善更为显著。除了改善情绪外，噻奈普汀还显著减轻了抑郁症患者的躯体不适。此外，如汉密尔顿焦虑评定量表总分变化所示，噻奈普汀具有抗焦虑活性，与阿米替林产生的效果相似。与阿米替林不同，噻奈普汀的抗焦虑活性并未伴有任何警觉性损害。噻奈普汀产生的抗胆碱能作用罕见且轻微。所得结果表明，噻奈普汀是一种有效的抗焦虑抑郁药，安全性优于阿米替林，适用于治疗酒精戒断后的情绪障碍。
