Sotnikova I V, Telesnina G N, Krakhmaleva I N, Sazykin Iu O, Navashin S M
Antibiot Khimioter. 1991 Aug;36(8):10-3.
Enzymes of various glycolysis stages, i.e. hexokinase, phosphofructokinase, pyruvate kinase and lactate dehydrogenase, were detected in cyclosporine-producing organisms belonging to Tolypocladium. The initial activity of the enzymes in the highly active strain was much higher than that in the starting low active strain. During the fermentation the activity of the glycolysis enzymes per 1 mg of mycelium protein in the both strains increased. This was accompanied by a decrease in respiration activity. Therefore, there was a direct correlation between cyclosporine biosynthesis and glycolytic activity of the mycelium in Tolypocladium sp.
在属于头孢霉属的产环孢素的生物体中检测到了糖酵解各个阶段的酶，即己糖激酶、磷酸果糖激酶、丙酮酸激酶和乳酸脱氢酶。高活性菌株中这些酶的初始活性远高于起始的低活性菌株。在发酵过程中，两株菌株每1毫克菌丝体蛋白中的糖酵解酶活性均增加。这伴随着呼吸活性的降低。因此，在头孢霉属中，环孢素生物合成与菌丝体的糖酵解活性之间存在直接关联。
