基于快速测序的病毒感染诊断
Rapid sequence-based diagnosis of viral infection.
作者信息
Quan Phenix-Lan, Briese Thomas, Palacios Gustavo, Lipkin W Ian
机构信息
Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, NY 10032, USA.
出版信息
Antiviral Res. 2008 Jul;79(1):1-5. doi: 10.1016/j.antiviral.2008.02.002. Epub 2008 Mar 7.
Abstract
With globalization of microbial threats and an increasing appreciation for the role of infection in chronic as well as acute diseases, there is burgeoning interest in the development of specific antiviral drugs. Less attention has been focused on the establishment and implementation of rapid viral diagnostic methods, without which it will not be possible to obtain the full benefit of new therapies. Here we review the current status of viral diagnostics and the utility of various sequence-based diagnostic platforms for applications in clinical microbiology, surveillance and pathogen discovery.
摘要
随着微生物威胁的全球化以及人们对感染在慢性和急性疾病中作用的认识不断提高，对特定抗病毒药物开发的兴趣迅速增长。人们较少关注快速病毒诊断方法的建立和实施，而没有这些方法就无法充分受益于新疗法。在此，我们综述病毒诊断的现状以及各种基于序列的诊断平台在临床微生物学、监测和病原体发现中的应用效用。
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