Department of Cell and Molecular Biology, Karolinska Institutet, 17177 Stockholm, Sweden.
Semin Cancer Biol. 2009 Dec;19(6):394-400. doi: 10.1016/j.semcancer.2009.07.005. Epub 2009 Jul 18.
Epidemiological and molecular evidence links Epstein-Barr virus (EBV) carriage to the pathogenesis of human malignancies of lymphoid and epithelial cell origin but the mechanisms of viral oncogenesis are poorly understood. Burkitt's lymphoma, a tumor occurring in both EBV-positive and -negative forms, provides a convenient model for analysis of the relative contribution of genetic changes and viral products that are expressed in the malignant cells. Here we review recent findings that highlight several mechanisms by which EBV could play an important role in oncogenesis by promoting genomic instability.
流行病学和分子证据将 Epstein-Barr 病毒（EBV）的携带与淋巴和上皮细胞来源的人类恶性肿瘤的发病机制联系起来，但病毒致癌的机制还知之甚少。伯基特淋巴瘤是一种同时存在 EBV 阳性和阴性形式的肿瘤，为分析遗传变化和在恶性细胞中表达的病毒产物的相对贡献提供了一个方便的模型。在这里，我们回顾了最近的发现，这些发现强调了 EBV 通过促进基因组不稳定性在致癌作用中发挥重要作用的几种机制。
