Ortonne Jean-Paul, Bissett Donald L
Department of Dermatology, Hospital L'Archet, University of Nice-Sophia Antipolis, Nice, France.
J Investig Dermatol Symp Proc. 2008 Apr;13(1):10-4. doi: 10.1038/jidsymp.2008.7.
Hyperpigmentary problems, including postinflammatory hyperpigmentation, solar lentigos, and melasma, occur widely in the human population and are thus of broad interest for control. On the basis of genomic and proteomic understanding of the melanocyte and melanogenesis, there are potentially hundreds of proteins and other effectors involved in pigmentation. This knowledge, although complex, should prove most useful in identifying specific abnormalities that lead to the hyperpigmentary problems. Also available are new laboratory screening methods and skin color measurement tools that are increasing the pace at which materials can be screened and evaluated clinically for their effectiveness. Combined with a clear consumer need for effective pigmentation control agents, advanced pigmentary system understanding and new research capabilities are setting the stage for future technological advancements.
色素沉着问题，包括炎症后色素沉着、日光性雀斑和黄褐斑，在人群中广泛存在，因此对其进行控制具有广泛的意义。基于对黑素细胞和黑素生成的基因组学和蛋白质组学的了解，可能有数百种蛋白质和其他效应物参与色素沉着过程。这些知识虽然复杂，但在识别导致色素沉着问题的特定异常方面应会非常有用。此外，新的实验室筛选方法和皮肤颜色测量工具也不断涌现，加快了临床上对各种材料进行筛选和评估其有效性的速度。鉴于消费者对有效色素沉着控制剂有着明确的需求，对色素系统的深入理解以及新的研究能力为未来的技术进步奠定了基础。
