Jiang Joy, Torok Natalie
Division of Gastroenterology and Hepatology, University of California Davis, Sacramento, USA.
Metab Syndr Relat Disord. 2008 Mar;6(1):1-7. doi: 10.1089/met.2007.0026.
Nonalcoholic fatty liver disease (NAFLD) is a major form of chronic liver disease in adults and children. It is one of the consequences of the current obesity epidemic, and can progress to nonalcoholic steatohepatitis (NASH), characterized by steatosis, inflammation, and progressive fibrosis, ultimately leading to cirrhosis and end-stage liver disease. The factors implicated in this progression are poorly understood. NASH is closely associated with obesity and the metabolic syndrome. Recent studies emphasize the role of insulin resistance, oxidative stress, lipid peroxidation, and cytokine release in the development of NASH. This review summarizes the current knowledge on the etiology and pathomechanism of NASH and the role of the metabolic syndrome in NASH development.
非酒精性脂肪性肝病（NAFLD）是成人和儿童慢性肝病的主要形式。它是当前肥胖流行的后果之一，可进展为非酒精性脂肪性肝炎（NASH），其特征为脂肪变性、炎症和进行性纤维化，最终导致肝硬化和终末期肝病。导致这种进展的因素尚不清楚。NASH与肥胖和代谢综合征密切相关。最近的研究强调了胰岛素抵抗、氧化应激、脂质过氧化和细胞因子释放在NASH发展中的作用。本综述总结了目前关于NASH病因和发病机制以及代谢综合征在NASH发展中的作用的知识。
