爱泼斯坦-巴尔病毒感染的虚拟视角：模拟机制
A virtual look at Epstein-Barr virus infection: simulation mechanism.
作者信息
Shapiro M, Duca K A, Lee K, Delgado-Eckert E, Hawkins J, Jarrah A S, Laubenbacher R, Polys N F, Hadinoto V, Thorley-Lawson D A
机构信息
Department of Pathology, Jaharis Building, Tufts University School of Medicine, 150 Harrison Ave., Boston, MA 02111, USA.
出版信息
J Theor Biol. 2008 Jun 21;252(4):633-48. doi: 10.1016/j.jtbi.2008.01.032. Epub 2008 Feb 16.
Abstract
Epstein-Barr virus (EBV) is an important human pathogen that establishes a life-long persistent infection and for which no precise animal model exists. In this paper, we describe in detail an agent-based model and computer simulation of EBV infection. Agents representing EBV and sets of B and T lymphocytes move and interact on a three-dimensional grid approximating Waldeyer's ring, together with abstract compartments for lymph and blood. The simulation allows us to explore the development and resolution of virtual infections in a manner not possible in actual human experiments. Specifically, we identify parameters capable of inducing clearance, persistent infection, or death.
摘要
爱泼斯坦-巴尔病毒（EBV）是一种重要的人类病原体，可引发终身持续性感染，目前尚无精确的动物模型。在本文中，我们详细描述了一种基于主体的模型以及EBV感染的计算机模拟。代表EBV以及B淋巴细胞和T淋巴细胞集合的主体在一个近似瓦尔代尔环的三维网格上移动并相互作用，同时还有淋巴和血液的抽象隔室。该模拟使我们能够以实际人体实验无法实现的方式探索虚拟感染的发展和消退。具体而言，我们确定了能够诱导清除、持续感染或死亡的参数。
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