Lecron J C, Morel F, Tanzer J, Gombert J, Goube de Laforest P
URA C.N.R.S. 1338, Hôpital La Milétrie, Poitiers, France.
Immunology. 1991 Nov;74(3):561-3.
Soluble CD23 (sCD23) enhances, in a dose-dependent manner, the number of secondary T-cell colonies generated by peripheral blood-derived agar T-colony cells in the presence of phytohaemagglutinin (PHA) and interleukin-2 (IL-2). This effect is not affected by IL-1 or IL-4 but is abolished by an anti-CD23 monoclonal antibody (mAb) or by IgE. No colonies were observed when sCD23 was added to PHA- or IL-2-free cultures. sCD23 also enhanced the cloning frequency of primary T-colony cells in a limiting dilution assay. These data provide the first direct evidence that sCD23 recruits T-cell clones in peripheral blood-born T cells and may be involved indirectly in the regulation of IgE response.
可溶性CD23（sCD23）在存在植物血凝素（PHA）和白细胞介素-2（IL-2）的情况下，以剂量依赖的方式增加外周血来源的琼脂T集落细胞产生的次级T细胞集落数量。这种作用不受IL-1或IL-4的影响，但可被抗CD23单克隆抗体（mAb）或IgE消除。当将sCD23添加到不含PHA或IL-2的培养物中时，未观察到集落。在有限稀释试验中，sCD23还提高了原代T集落细胞的克隆频率。这些数据提供了首个直接证据，表明sCD23在外周血源性T细胞中募集T细胞克隆，并且可能间接参与IgE反应的调节。
