腹部肥胖、血糖和载脂蛋白B水平是健康成年人中高胆固醇血症（2001 - 2006年）发病率的最佳预测指标：阿提卡研究。
Abdominal obesity, blood glucose and apolipoprotein B levels are the best predictors of the incidence of hypercholesterolemia (2001-2006) among healthy adults: the ATTICA study.
作者信息
Panagiotakos Demosthenes B, Pitsavos Christos, Skoumas Yannis, Lentzas Yannis, Papadimitriou Labros, Chrysohoou Christina, Stefanadis Christodoulos
机构信息
Department of Dietetics - Nutrition, Harokopio University, Athens, Greece.
出版信息
Lipids Health Dis. 2008 Mar 31;7:11. doi: 10.1186/1476-511X-7-11.
OBJECTIVE
In this work we evaluated the 5-year incidence of hypercholesterolemia, in a sample of cardiovascular disease free adult men and women from Greece. We also evaluated the association of several socio-demographic, dietary and lifestyle habits on the incidence of this disorder.
METHODS
1514 men and 1528 women (>18 y) without any clinical evidence of cardiovascular disease, living in Attica area, Greece, were enrolled in the ATTICA study from May 2001 to December 2002. The sampling was random, multi-stage, and included information about various socio-demographic, lifestyle (diet, exercise, smoking etc), biological (lipids, and inflammatory markers), and clinical characteristics of the participants. In 2006, a group of experts performed the 5-year follow-up through telephone calls or personal visits (941 of the 3042 (31%) participants were lost to follow-up). Hypercholesterolemia, among people who had normal blood lipids at initial examination, was defined as fasting total cholesterol levels > 200 mg/dl or use of lipids lowering agents (NCEP ATPIII).
RESULTS
The 5-year incidence of hypercholesterolemia was 23.7% (n = 127) in men and 17.7% (n = 110) in women (p for gender differences < 0.001). Multi-adjusted logistic regression analysis which revealed that increased age (odds ratio = 1.05, p < 0.001), waist circumference (odds ratio = 1.02, p = 0.03), fasting blood glucose (odds ratio = 1.01, p = 0.08) and apolipoprotein B (odds ratio = 1.02, p = 0.001) levels, were the most significant baseline predictors of developing hypercholesterolemia within a 5-year period.
CONCLUSION
Incidence of hypercholesterolemia was high in both genders, emphasizing the burden of this disorder at population level. Aging, increased waist circumference, fasting blood glucose and apolipoprotein B levels were the most significant baseline predictors of hypercholesterolemia.
目的
在这项研究中，我们评估了来自希腊的无心血管疾病成年男性和女性样本中高胆固醇血症的5年发病率。我们还评估了一些社会人口学、饮食和生活方式习惯与这种疾病发病率之间的关联。
方法
2001年5月至2002年12月，1514名男性和1528名女性（>18岁），居住在希腊阿提卡地区，且无任何心血管疾病临床证据，被纳入阿提卡研究。抽样是随机、多阶段的，包括有关参与者各种社会人口学、生活方式（饮食、运动、吸烟等）、生物学（血脂和炎症标志物）以及临床特征的信息。2006年，一组专家通过电话或个人拜访进行了5年随访（3042名参与者中有941名（31%）失访）。在初次检查血脂正常的人群中，高胆固醇血症被定义为空腹总胆固醇水平>200mg/dl或使用降脂药物（美国国家胆固醇教育计划成人治疗组第三次报告）。
结果
男性高胆固醇血症的5年发病率为23.7%（n = 127），女性为17.7%（n = 110）（性别差异p<0.001）。多因素调整逻辑回归分析显示，年龄增加（比值比 = 1.05，p<0.001）、腰围（比值比 = 1.02，p = 0.03）、空腹血糖（比值比 = 1.01，p = 0.08）和载脂蛋白B水平（比值比 = 1.02，p = 0.001）是5年内发生高胆固醇血症最显著的基线预测因素。
结论
高胆固醇血症在男女中的发病率都很高，强调了这种疾病在人群层面的负担。年龄增长、腰围增加、空腹血糖和载脂蛋白B水平是高胆固醇血症最显著的基线预测因素。
Zotero 插件