Patton George C, Coffey Carolyn, Carlin John B, Sanci Lena, Sawyer Susan
William Buckland House, Parkville, Victoria, Australia.
Br J Psychiatry. 2008 Apr;192(4):294-9. doi: 10.1192/bjp.bp.106.031112.
Partial syndromes of eating disorder are common in adolescents but the health significance of these syndromes remains uncertain.
To document the health and social adjustment in young adulthood of females assessed as having a partial syndrome of eating disorder in adolescence.
A community sample of 1943 participants was tracked over 10 years in an eight-wave cohort study. A partial syndrome was defined as the fulfilment of at least two DSM-IV criteria for either anorexia or bulimia nervosa at one assessment or more between the ages of 15 years and 17 years.
Partial syndromes were found in 9.4% of 15- to 17-year-old female participants and 1.4% of males. There were few instances of progression of partial syndromes to fully fledged anorexia and bulimia nervosa. However, among those with partial syndromes depressive and anxiety symptoms were two to three times higher in young adulthood, substance misuse was common, and a majority of those with a partial syndrome of anorexia nervosa were still underweight in their mid-20s.
Given the level of subsequent psychopathology and social role impairment, there may be justification for initiating trials of preventive and early clinical intervention strategies for adolescent partial syndromes.
饮食失调的部分综合征在青少年中很常见，但这些综合征对健康的影响仍不确定。
记录在青少年时期被评估为患有饮食失调部分综合征的女性在成年早期的健康状况和社会适应情况。
在一项八波队列研究中，对1943名参与者的社区样本进行了为期10年的跟踪。部分综合征被定义为在15岁至17岁之间的一次或多次评估中，至少满足两条DSM-IV厌食症或神经性贪食症标准。
在15至17岁的女性参与者中，9.4%发现有部分综合征，男性为1.4%。部分综合征发展为完全成熟的厌食症和神经性贪食症的情况很少。然而，在患有部分综合征的人群中，成年早期的抑郁和焦虑症状高出两到三倍，药物滥用很常见，大多数患有神经性厌食症部分综合征的人在25岁左右体重仍不足。
鉴于随后的精神病理学水平和社会角色损害程度，或许有理由针对青少年部分综合征开展预防和早期临床干预策略的试验。
