三（吡唑基）甲烷（tpm）三羰基锰配合物的光致一氧化碳释放、细胞摄取及细胞毒性
Photoinduced CO release, cellular uptake and cytotoxicity of a tris(pyrazolyl)methane (tpm) manganese tricarbonyl complex.
作者信息
Niesel Johanna, Pinto Antonio, Peindy N'Dongo Harmel W, Merz Klaus, Ott Ingo, Gust Ronald, Schatzschneider Ulrich
机构信息
Lehrstuhl für Anorganische Chemie I-Bioanorganische Chemie, Ruhr-Universität Bochum NC 3/74, Universitätsstrasse 150, D-44801 Bochum, Germany.
出版信息
Chem Commun (Camb). 2008 Apr 21(15):1798-800. doi: 10.1039/b719075a. Epub 2008 Feb 8.
DOI:10.1039/b719075a
PMID:18379697
Abstract
Cell viability studies of HT29 colon cancer cells treated with the CO-releasing compound [Mn(CO)(3)(tpm)]PF(6) revealed a significant photoinduced cytotoxicity comparable to that of established agent 5-fluorouracil (5-FU), while controls kept in the dark were unaffected at up to 100 microM.
摘要
用一氧化碳释放化合物[Mn(CO)(3)(tpm)]PF(6)处理HT29结肠癌细胞的细胞活力研究表明，其具有显著的光诱导细胞毒性，可与已确立的药物5-氟尿嘧啶（5-FU）相媲美，而置于黑暗中的对照组在浓度高达100微摩尔时不受影响。
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