Jones R W, Wesnes K A, Kirby J
Research Institute for the Care of the Elderly, St. Martin's Hospital, Bath, UK.
Ann N Y Acad Sci. 1991;640:241-4. doi: 10.1111/j.1749-6632.1991.tb00226.x.
D-Cycloserine is a partial agonist at the strychnine-insensitive neuronal glycine receptor and positively modulates the N-methyl-D-aspartate (NMDA) excitatory amino acid receptor. NMDA receptors appear to be important in learning and memory, and D-cycloserine facilitates learning in rats. In man, central cholinergic blockade due to scopolamine administration impairs attention, information processing, and memory for new information, the latter secondary memory impairments resembling those shown in patients with Alzheimer's disease (AD). D-Cycloserine has been studied for its ability to counteract the cognitive decrements produced by scopolamine in young and elderly healthy volunteers. D-Cycloserine specifically antagonized the memory impairments produced by scopolamine. These findings provide evidence of NMDA receptor involvement in human memory and suggest a novel mechanism for alleviation of memory loss associated with aging and dementia.
D-环丝氨酸是对士的宁不敏感的神经元甘氨酸受体的部分激动剂，可正向调节N-甲基-D-天冬氨酸（NMDA）兴奋性氨基酸受体。NMDA受体在学习和记忆中似乎很重要，D-环丝氨酸可促进大鼠的学习。在人类中，东莨菪碱给药导致的中枢胆碱能阻滞会损害注意力、信息处理以及对新信息的记忆，后者的继发性记忆损害类似于阿尔茨海默病（AD）患者所表现出的情况。已对D-环丝氨酸对抗东莨菪碱在年轻和老年健康志愿者中产生的认知衰退的能力进行了研究。D-环丝氨酸特异性拮抗东莨菪碱产生的记忆损害。这些发现为NMDA受体参与人类记忆提供了证据，并提示了一种缓解与衰老和痴呆相关的记忆丧失的新机制。
