Marcucci F, Riva R, Gomeni R, Zavattini G, Lacombe P S, Mussini E
J Pharm Sci. 1978 May;67(5):705-6. doi: 10.1002/jps.2600670537.
The distribution of ditazole in blood and tissues of rats was determined by a simple GLC technique. Ditazole, after intravenous injection in rats (20 mg/kg), entered preferentially into the brain, the liver, and the heart in decreasing order. In the epididymal adipose tissue, the drug was present only in small amounts. Ditazole disappeared from the rat organs 4 hr after the treatment. The apparent ditazole half-life in rat blood was 41 min, the volume of distribution was 2.068 liters/kg, and the body clearance was 0.0345 liter/kg/min.
采用一种简单的气相色谱技术测定了地他唑在大鼠血液和组织中的分布情况。大鼠静脉注射地他唑（20毫克/千克）后，药物优先进入脑、肝和心脏，顺序递减。在附睾脂肪组织中，药物含量仅很少。给药后4小时，地他唑从大鼠器官中消失。地他唑在大鼠血液中的表观半衰期为41分钟，分布容积为2.068升/千克，机体清除率为0.0345升/千克/分钟。
