Duiverman M L, Wempe J B, Bladder G, Kerstjens H A M, Wijkstra P J
Dept of Pulmonary Diseases, University Medical Center Groningen, University of Groningen, Post box 30002, 9750 RA Haren, The Netherlands.
Eur Respir J. 2008 Aug;32(2):379-86. doi: 10.1183/09031936.00163607. Epub 2008 Apr 2.
The Maugeri Respiratory Failure (MRF-28) and Severe Respiratory Insufficiency (SRI) questionnaires were recently developed to assess health-related quality of life (HRQoL) in patients with chronic respiratory failure, although not exclusively in chronic obstructive pulmonary disease (COPD) patients. The aim of the present study was to investigate whether the MRF-28 and SRI are reliable and valid HRQoL questionnaires in COPD patients with chronic hypercapnic respiratory failure (CHRF). In total, 72 COPD patients with CHRF underwent pulmonary function and exercise testing, and completed the MRF-28, the SRI, the Chronic Respiratory Questionnaire (CRQ), the Hospital Anxiety and Depression Scale, the Groningen Activity and Restriction Scale and two dyspnoea indexes. Physical domain scores of the questionnaires correlated with exercise tolerance, dyspnoea and daily activities, while psychological domains correlated strongly with anxiety and depression. Anxiety scores accounted for 51 and 56% of the total explained variance in total CRQ and SRI scores, respectively. The emphasis of the MRF-28 was restrictions in activities of daily living (52% of total variance). In conclusion, the present study showed that the Maugeri Respiratory Failure and Severe Respiratory Insufficiency questionnaires were reliable and valid questionnaires in chronic obstructive pulmonary disease patients with chronic hypercapnic respiratory failure. While the emphasis in the Maugeri Respiratory Failure questionnaire is on activities of daily living, the Severe Respiratory Insufficiency questionnaire, like the Chronic Respiratory Questionnaire, is more related to anxiety and depression.
毛杰里呼吸衰竭（MRF - 28）问卷和严重呼吸功能不全（SRI）问卷最近被开发出来，用于评估慢性呼吸衰竭患者与健康相关的生活质量（HRQoL），不过并不局限于慢性阻塞性肺疾病（COPD）患者。本研究的目的是调查MRF - 28和SRI问卷在患有慢性高碳酸血症呼吸衰竭（CHRF）的COPD患者中是否为可靠且有效的HRQoL问卷。共有72例患有CHRF的COPD患者接受了肺功能和运动测试，并完成了MRF - 28问卷、SRI问卷、慢性呼吸问卷（CRQ）、医院焦虑抑郁量表、格罗宁根活动与限制量表以及两个呼吸困难指数。问卷的身体领域得分与运动耐量、呼吸困难和日常活动相关，而心理领域得分与焦虑和抑郁密切相关。焦虑得分分别占CRQ总分和SRI总分解释变异的51%和56%。MRF - 28问卷的重点是日常生活活动受限（占总变异的52%）。总之，本研究表明，毛杰里呼吸衰竭问卷和严重呼吸功能不全问卷在患有慢性高碳酸血症呼吸衰竭的慢性阻塞性肺疾病患者中是可靠且有效的问卷。虽然毛杰里呼吸衰竭问卷的重点是日常生活活动，但严重呼吸功能不全问卷与慢性呼吸问卷一样，与焦虑和抑郁的关系更大。
