O'Connell E A, Steere H A, Trott N G
Br J Radiol. 1976 Sep;49(585):779-87. doi: 10.1259/0007-1285-49-585-779.
A quantitative, digital-output, whole-body scanner in a low background area has been used in the dosimetry of 32P/131I Lipiodol for intralymphatic radiotherapy. Five patients with malignant melanoma received intralymphatic administrations of Lipiodol labelled with 6 mCi 32P and 1.5 mCi 131I. The 131I is used primarily as a tracer for external measurements and the 32P as the chief therapeutic agent. Whole body scans were made at intervals for up to 15 days using the digital scanner, with the spectrometer set over the 364 keV photopeak of 131I. On the same occasions complete gamma-spectra were obtained for these patients using a 2 m arc, single detector whole body counter. The method used in estimating the activity at various sites in the body from the digital whole body scans is described and problems that arise in using 131I as a tracer for 32P Lipiodol in this work are discussed. For the administered activities mentioned above, maximum absorbed doses to the lymph nodes were found to range from 30-96 krad with a mean value of 51 krad. Uptake of radioactivity was also found in the lungs, resulting in absorbed doses of 350-960 rad with a mean value of 540 rad.
在低本底区域使用一台定量、数字输出的全身扫描仪对用于淋巴内放疗的32P/131I碘油进行剂量测定。5例恶性黑色素瘤患者接受了用6毫居里32P和1.5毫居里131I标记的碘油的淋巴内给药。131I主要用作外部测量的示踪剂，32P用作主要治疗剂。使用数字扫描仪每隔一定时间进行全身扫描，最长持续15天，能谱仪设置在131I的364keV光峰上。在相同情况下，使用2米弧单探测器全身计数器为这些患者获取完整的伽马能谱。描述了从数字全身扫描估计身体各部位活度的方法，并讨论了在这项工作中使用131I作为32P碘油示踪剂时出现的问题。对于上述给药活度，发现淋巴结的最大吸收剂量范围为30 - 96拉德，平均值为51拉德。还发现肺部有放射性摄取，导致吸收剂量为350 - 960拉德，平均值为540拉德。
