Keoluangkhot Valy, Green Michael D, Nyadong Leonard, Fernández Facundo M, Mayxay Mayfong, Newton Paul N
Adult Infectious Disease Ward, Mahosot Hospital, Vientiane, Lao PDR.
Am J Trop Med Hyg. 2008 Apr;78(4):552-5.
We describe an adult with uncomplicated Plasmodium falciparum malaria who did not improve clinically despite 5 days of intramuscular artemether therapy. He was prescribed a lower dose (kg body weight) than that recommended, and a vial from the packet contained only 74% of the artemether dose as stated by the manufacturer. The combination of underdosing, poor-quality drug, and the intrinsic low bioavailability of artemether may have contributed to his poor clinical response. Analysis of the packaging and chemical "fingerprinting" of the artemether suggested that the drug was genuine but was either substandard or had deteriorated after manufacture.
我们描述了一名患有单纯性恶性疟原虫疟疾的成年人，尽管接受了5天的肌肉注射蒿甲醚治疗，但临床症状并未改善。给他开的剂量（按体重计算）低于推荐剂量，而且药包中的一小瓶蒿甲醚含量仅为制造商标明剂量的74%。剂量不足、药物质量差以及蒿甲醚本身较低的生物利用度可能导致了他临床反应不佳。对蒿甲醚包装和化学“指纹图谱”的分析表明，该药物是正品，但要么是不合格产品，要么是生产后已经变质。
