Louro J, Pearse D D
The Miami Project to Cure Paralysis, University of Miami School of Medicine, Miami, FL 33136, USA.
Neurol Res. 2008 Feb;30(1):5-16. doi: 10.1179/174313208X284070.
Mechanical trauma to the spinal cord is often accompanied by irreversible tissue damage, limited endogenous repair and permanent loss of motor, sensory and autonomic function. The implantation of exogenous cells or the stimulation of endogenous cells, to repopulate and replace or to provide a conducive environment for repair, offers a promising therapeutic direction for overcoming the multitude of obstacles facing successful recovery from spinal cord injury. Although relatively new to the scene of cell based therapies for reparative medicine, stem cells and their progenitors have been labeled as the 'cell of the future' for revolutionizing the treatment of CNS injury and neurodegenerative disorders. The following review examines the different types of stem cells and their progenitors, their utility in experimental models of spinal cord injury and explores the outstanding issues that still need to be addressed before they move towards clinical implementation.
脊髓机械性创伤常伴有不可逆的组织损伤、有限的内源性修复以及运动、感觉和自主神经功能的永久性丧失。植入外源性细胞或刺激内源性细胞以重新填充和替代，或为修复提供有利环境，为克服脊髓损伤成功恢复面临的众多障碍提供了一个有前景的治疗方向。尽管在再生医学基于细胞的治疗领域中相对较新，但干细胞及其祖细胞已被视为“未来的细胞”，有望彻底改变中枢神经系统损伤和神经退行性疾病的治疗方式。以下综述探讨了不同类型的干细胞及其祖细胞、它们在脊髓损伤实验模型中的效用，并探讨了在迈向临床应用之前仍需解决的突出问题。
