震颤随深部脑刺激的时间规律性而变化。
Tremor varies as a function of the temporal regularity of deep brain stimulation.
作者信息
Birdno Merrill J, Kuncel Alexis M, Dorval Alan D, Turner Dennis A, Grill Warren M
机构信息
Biomedical Engineering, Duke University, Duke University Medical Center, Durham, North Carolina 27708-0281, USA.
出版信息
Neuroreport. 2008 Mar 26;19(5):599-602. doi: 10.1097/WNR.0b013e3282f9e45e.
Abstract
The frequency of stimulation is one of the primary factors determining the effectiveness of deep brain stimulation (DBS) in relieving tremor. DBS efficacy, however, may depend not only on the average frequency of stimulation, but also on the temporal pattern of stimulation. We conducted intraoperative measurements of the effect of temporally irregular DBS (nonconstant interpulse intervals) on tremor. As the coefficient of variation of irregular high frequency DBS trains increased, they became less effective at reducing tremor (mixed effects regression model, P<0.04). These data provide evidence that the effects of DBS are dependent not only on the average frequency of DBS, but also on the regularity of the temporal spacing of DBS pulses.
摘要
刺激频率是决定深部脑刺激（DBS）缓解震颤有效性的主要因素之一。然而，DBS的疗效可能不仅取决于平均刺激频率，还取决于刺激的时间模式。我们对时间不规则的DBS（脉冲间期不恒定）对震颤的影响进行了术中测量。随着不规则高频DBS序列变异系数的增加，它们在减轻震颤方面的效果变得更差（混合效应回归模型，P<0.04）。这些数据表明，DBS的效果不仅取决于DBS的平均频率，还取决于DBS脉冲时间间隔的规律性。
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