Siroux V, Boudier A, Anto J M, Cazzoletti L, Accordini S, Alonso J, Cerveri I, Corsico A, Gulsvik A, Jarvis D, de Marco R, Marcon A, Marques E A, Bugiani M, Janson C, Leynaert B, Pin I
INSERM, U823, Grenoble, France.
Allergy. 2008 May;63(5):547-54. doi: 10.1111/j.1398-9995.2008.01638.x.
Health-related quality-of-life (HRQL) has been poorly studied in large samples of asthmatics from the general population. HRQL and its relationship to asthma-severity were assessed among 900 asthmatics enrolled in the European Community Respiratory Health Survey.
Among asthmatics, 864 completed the short form-36 (SF-36) questionnaire and 477 also completed the Asthma Quality-of-life Questionnaire (AQLQ). A 4-class asthma-severity scale, combining clinical items, forced expiratory volume in 1 s and the level of treatment and the different asthma-severity components (each of the clinical items and hospitalization) were studied in relation to HRQL.
Mean SF-36 Physical Component Summary (PCS) and Mental Component Summary (MCS) scores (45.5 and 48.8 respectively) were lower than expected in a general population. The mean total AQLQ score was 5.8. The AQLQ score and to a lesser extent the PCS score were significantly related to the 4-class asthma-severity scale, although the risk of having a lower HRQL score did not vary proportionally across the levels of severity. Asthma-severity had no impact on the MCS score. Asthma attack frequency and hospitalization were associated with both total AQLQ and PCS scores, whereas nocturnal symptoms and lung function were more strongly related to the AQLQ and PCS score respectively.
In population-based asthmatics, the specific AQLQ questionnaire, and also to a lesser extent the generic SF-36 questionnaire, were sensitive to asthma-severity. Frequencies of asthma attacks, of nocturnal symptoms and hospitalization for asthma have independent impact on HRQL.
在来自普通人群的大量哮喘患者样本中，与健康相关的生活质量（HRQL）研究较少。在参与欧洲共同体呼吸健康调查的900名哮喘患者中评估了HRQL及其与哮喘严重程度的关系。
在哮喘患者中，864人完成了简短健康调查问卷（SF-36），477人还完成了哮喘生活质量问卷（AQLQ）。研究了一种结合临床项目、一秒用力呼气量、治疗水平的四级哮喘严重程度量表以及不同的哮喘严重程度组成部分（每个临床项目和住院情况）与HRQL的关系。
SF-36身体成分总结（PCS）和心理成分总结（MCS）分数的平均值（分别为45.5和48.8）低于普通人群的预期值。AQLQ总得分的平均值为5.8。AQLQ得分以及在较小程度上PCS得分与四级哮喘严重程度量表显著相关，尽管HRQL得分较低的风险在不同严重程度水平上并非成比例变化。哮喘严重程度对MCS得分没有影响。哮喘发作频率和住院与AQLQ总分和PCS得分均相关，而夜间症状和肺功能分别与AQLQ和PCS得分的相关性更强。
在基于人群的哮喘患者中，特定的AQLQ问卷以及在较小程度上通用的SF-36问卷对哮喘严重程度敏感。哮喘发作频率、夜间症状和哮喘住院对HRQL有独立影响。
