植物雌激素对生殖健康的不良影响：三例报告

Adverse effects of phytoestrogens on reproductive health: a report of three cases.

作者信息

Chandrareddy Ashadeep, Muneyyirci-Delale Ozgul, McFarlane Samy I, Murad Omar M

机构信息

Division of Reproductive Endocrinology and Infertility, SUNY Downstate Medical Center, Kings County Hospital Center, 450 Clarkson Avenue, Brooklyn, NY 11203, USA.

出版信息

Complement Ther Clin Pract. 2008 May;14(2):132-5. doi: 10.1016/j.ctcp.2008.01.002. Epub 2008 Mar 7.

DOI:10.1016/j.ctcp.2008.01.002

PMID:18396257

Abstract

BACKGROUND

Phytoestrogens have been thought to have favorable effects on women's health and perhaps in offsetting cancers. The possible adverse effects of phytoestrogens have not been evaluated.

CASES

Abnormal uterine bleeding with endometrial pathology in three women was found to be related to a high intake of soy products. The first woman had postmenopausal bleeding with uterine polyp, proliferative endometrium and a growing leiomyoma. The second woman presented with severe dysmenorrhea, abnormal uterine bleeding, endometriosis and uterine leiomyoma not responding to treatment. The third woman with severe dysmenorrhea, abnormal uterine bleeding, endometriosis and uterine leiomyomata presented with secondary infertility. All three women improved after withdrawal of soy from their diet.

CONCLUSION

Additional information on phytoestrogens is necessary to ascertain their safety before they can be routinely used as supplements.

摘要

背景

植物雌激素被认为对女性健康有有益影响，或许还能预防癌症。植物雌激素可能存在的不良影响尚未得到评估。

病例

三名女性出现伴有子宫内膜病变的异常子宫出血，发现这与大量摄入豆制品有关。第一名女性绝经后出血，伴有子宫息肉、增生性子宫内膜和逐渐增大的平滑肌瘤。第二名女性表现为严重痛经、异常子宫出血、子宫内膜异位症和子宫平滑肌瘤，治疗无效。第三名女性有严重痛经、异常子宫出血、子宫内膜异位症和子宫平滑肌瘤，并出现继发性不孕。所有三名女性在饮食中停止食用大豆后病情均有改善。