Eren Mittra, Fabri Mario, Krieg Thomas, Eming Sabine A
Department of Dermatology, Venerology und Allergology, University of Cologne, Cologne, Germany.
J Am Acad Dermatol. 2008 Jun;58(6):1056-8. doi: 10.1016/j.jaad.2008.02.034. Epub 2008 Apr 8.
Pustulosis acuta generalisata (PAG) is a rare poststreptococcal disease of the skin, which has been reported in children and adults after streptococcal throat infection. Herein, we report on the case of a 47-year-old woman with typical clinical and histologic findings of PAG emerging after a pharyngeal infection in whom inflammatory joint-involvement developed. The patient was found to be HLA-A2 and HLA-B35 positive. Whereas HLA-B35 might be associated with pustular skin diseases, HLA-A2 is a risk factor for the development of rheumatoid arthritis.
泛发性急性脓疱病（PAG）是一种罕见的链球菌感染后皮肤疾病，已报道在儿童和成人的链球菌性咽喉感染后发病。在此，我们报告一例47岁女性病例，该患者在咽部感染后出现典型的PAG临床和组织学表现，并发生了炎症性关节受累。发现该患者HLA-A2和HLA-B35呈阳性。虽然HLA-B35可能与脓疱性皮肤病有关，但HLA-A2是类风湿关节炎发生的一个危险因素。
