Mallol-Mesnard Nathalie, Menegaux Florence, Lacour Brigitte, Hartmann Olivier, Frappaz Didier, Doz François, Bertozzi Anne-Isabelle, Chastagner Pascal, Hémon Denis, Clavel Jacqueline
INSERM, U754 Villejuif, France; Universite de Paris-Sud, UMR-S754, IFR69 Villejuif, France.
Cancer Detect Prev. 2008;32(1):79-86. doi: 10.1016/j.cdp.2008.02.003. Epub 2008 Apr 8.
Determining the role of pre- and perinatal factors in the aetiology of childhood malignant central nervous (CNS) tumors, using data from the French national case-control study, ESCALE.
ESCALE included all children in France less than 15 years old with a diagnosis of acute leukaemia, lymphoma, malignant CNS tumor, or neuroblastoma (2003-2004). In all, 209 malignant CNS tumor cases (80% of the eligible cases) and 1681 population-based controls (71%) were included using quotas ensuring frequency matching with the cases by age and gender. Case and control mothers were interviewed using a standardised telephone interview, which elicited birth characteristics, congenital malformation, maternal reproductive history, and use of assisted reproductive technologies for the index child.
The cases and controls did not differ in terms of gestational age at birth, birth weight, birth order, breastfeeding, or parental age at birth. There was no association between assisted reproduction for the index child and malignant CNS tumor (OR=1.1 [0.6-2.2]). A positive association between a maternal history of one miscarriage and malignant CNS tumor was observed (OR=1.4 [1.0-2.0], p<0.05), especially for glial cell tumors (other glioma: OR=2.0 [1.1-3.6]).
The results suggest a possible association between a maternal history of one miscarriage and the risk of malignant CNS tumor.
利用法国全国性病例对照研究ESCALE的数据，确定产前和围产期因素在儿童恶性中枢神经系统（CNS）肿瘤病因学中的作用。
ESCALE纳入了法国所有15岁以下诊断为急性白血病、淋巴瘤、恶性CNS肿瘤或神经母细胞瘤的儿童（2003 - 2004年）。总共纳入了209例恶性CNS肿瘤病例（占符合条件病例的80%）和1681名基于人群的对照（占71%），采用配额法确保按年龄和性别与病例进行频率匹配。对病例组和对照组的母亲进行标准化电话访谈，询问有关索引儿童的出生特征、先天性畸形、母亲生育史以及辅助生殖技术的使用情况。
病例组和对照组在出生孕周、出生体重、出生顺序、母乳喂养或父母生育年龄方面没有差异。索引儿童的辅助生殖与恶性CNS肿瘤之间没有关联（比值比[OR]=1.1[0.6 - 2.2]）。观察到母亲有一次流产史与恶性CNS肿瘤之间存在正相关（OR=1.4[1.0 - 2.0]，p<0.05），尤其是对于胶质细胞瘤（其他胶质瘤：OR=2.0[1.1 - 3.6]）。
结果表明母亲有一次流产史与恶性CNS肿瘤风险之间可能存在关联。
