Tykarski A, Oko-Sarnowska Z, Skołuda A
Kliniki Nadciśnienia Tetniczego Instytutu Kardiologii AM w Poznaniu.
Pol Arch Med Wewn. 1991 Sep;86(3):183-8.
In forty patients with essential hypertension correlation between serum uric acid and some clinical features of hypertensive disease i.e. severity and time of duration of arterial hypertension, the extent of vascular, retinal changes and left ventricular wall thickness was evaluated. Results showed that diastolic arterial pressure and the extent of retinal changes are significantly higher in hypertensive patients with concomitant hyperuricemia in comparison with normal uricemia patients with essential hypertension. Positive correlation was found between serum uric acid and diastolic as well as mean arterial pressure. Moreover, patients with essential hypertension and hyperuricemia demonstrated left ventricular hypertrophy in comparison with normal uricemia in hypertensive patients. Elevated serum uric acid in essential hypertension should be regarded as an early "harbinger" of disposition to the quick progress of vascular changes.
对40例原发性高血压患者血清尿酸与高血压病的一些临床特征，即动脉高血压的严重程度和病程时间、血管及视网膜病变程度以及左心室壁厚度之间的相关性进行了评估。结果显示，与原发性高血压尿酸正常的患者相比，伴有高尿酸血症的高血压患者舒张压及视网膜病变程度明显更高。血清尿酸与舒张压及平均动脉压之间呈正相关。此外，与高血压尿酸正常的患者相比，原发性高血压合并高尿酸血症的患者表现出左心室肥厚。原发性高血压患者血清尿酸升高应被视为血管病变快速进展倾向的早期“先兆”。
