[Uric acid and arterial hypertension. IV. Relation between serum uric acid level, the extent of vascular changes and heart enlargement in primary arterial hypertension].

In forty patients with essential hypertension correlation between serum uric acid and some clinical features of hypertensive disease i.e. severity and time of duration of arterial hypertension, the extent of vascular, retinal changes and left ventricular wall thickness was evaluated. Results showed that diastolic arterial pressure and the extent of retinal changes are significantly higher in hypertensive patients with concomitant hyperuricemia in comparison with normal uricemia patients with essential hypertension. Positive correlation was found between serum uric acid and diastolic as well as mean arterial pressure. Moreover, patients with essential hypertension and hyperuricemia demonstrated left ventricular hypertrophy in comparison with normal uricemia in hypertensive patients. Elevated serum uric acid in essential hypertension should be regarded as an early "harbinger" of disposition to the quick progress of vascular changes.