Pyne Jeffrey M, French Michael, McCollister Kathryn, Tripathi Shanti, Rapp Richard, Booth Brenda
Center for Mental Health and Outcomes Research, Central Arkansas Veterans Healthcare System, Little Rock, AR 72114, USA.
Addiction. 2008 Aug;103(8):1320-9; discussion 1330-2. doi: 10.1111/j.1360-0443.2008.02153.x. Epub 2008 Apr 7.
Examine the validity of preference-weighted health-related quality of life measures in a sample of substance use disorder (SUD) patients. The implications of cost-utility analyses (CUAs) of SUD interventions are discussed.
Cross-sectional analysis of subjects seeking SUD treatment.
Seven SUD treatment centers in a medium-sized Midwestern metropolitan area in the United States.
Data from 574 SUD subjects were analyzed from a study to test interventions to improve linkage and engagement with substance abuse treatment.
Subjects completed the following preference-weighted measures: self-administered Quality of Well-Being scale (QWB-SA) and Medical Outcomes Study SF-12 (standard gamble weighted or SF-12 SG); and clinical measures: Addiction Severity Index (ASI) and a symptom checklist based on the DSM-IV.
In unadjusted analyses, the QWB-SA was correlated significantly with six of seven ASI subscales and the SF-12 SG was correlated with four of seven. In adjusted analyses, both preference-weighted measures were significantly correlated with diagnostic, physical health, mental health and drug use measures, but not with legal or alcohol use measures. The QWB-SA was also correlated with employment problems and the SF-12 SG was correlated with family/social problems.
This study generally supports the construct validity of preference-weighted health-related quality of life measures in SUD patients. However, the QWB-SA and SF-12 SG did not correlate with all ASI scales. Cost-benefit analysis may be preferable when policy-makers are interested in evaluating the full range of SUD intervention outcomes.
在物质使用障碍（SUD）患者样本中检验偏好加权的健康相关生活质量测量方法的有效性。讨论SUD干预措施的成本效用分析（CUA）的意义。
对寻求SUD治疗的受试者进行横断面分析。
美国中西部一个中等规模大都市地区的七个SUD治疗中心。
对574名SUD受试者的数据进行分析，该数据来自一项测试改善物质滥用治疗的联系和参与度的干预措施的研究。
受试者完成以下偏好加权测量：自我管理的幸福感量表（QWB-SA）和医学结果研究SF-12（标准博弈加权或SF-12 SG）；以及临床测量：成瘾严重程度指数（ASI）和基于《精神疾病诊断与统计手册》第四版的症状清单。
在未经调整的分析中，QWB-SA与ASI七个分量表中的六个显著相关，SF-12 SG与七个中的四个相关。在调整后的分析中，两种偏好加权测量均与诊断、身体健康、心理健康和药物使用测量显著相关，但与法律或酒精使用测量无关。QWB-SA还与就业问题相关，SF-12 SG与家庭/社会问题相关。
本研究总体上支持SUD患者中偏好加权的健康相关生活质量测量方法的结构效度。然而，QWB-SA和SF-12 SG与所有ASI量表均不相关。当政策制定者有兴趣评估SUD干预措施的全部结果时，成本效益分析可能更可取。
