Center for Mental Healthcare and Outcomes Research, Central Arkansas Veterans Healthcare System, Little Rock, USA.
Addiction. 2011 Mar;106(3):507-15. doi: 10.1111/j.1360-0443.2010.03299.x.
To examine the construct validity of generic preference-weighted health-related quality of life measures in a sample of patients with a substance use disorder (SUD).
Longitudinal (baseline and 6-month follow-up) data from a research study that evaluated interventions to improve linkage and engagement with SUD treatment.
A central intake unit that referred patients to seven SUD treatment centers in a Midwestern US metropolitan area.
A total of 495 individuals with a SUD.
Participants completed two preference-weighted measures: the self-administered Quality of Well-Being scale (QWB-SA) and the standard gamble weighted Medical Outcomes Study SF-12 (SF-6D). They were also administered two clinical assessments: all seven domains of the Addiction Severity Index (ASI) and a symptom checklist based on the DSM-IV. Construct validity was determined via the relationships between disease-specific SUD and generic measures.
In unadjusted analyses, the QWB-SA and SF-6D change scores were correlated significantly with six ASI subscale change scores, but not with employment status. In adjusted repeated-measures analyses, three of seven ASI subscale scores were significant predictors of QWB-SA and 5/7 ASI subscale scores were significant predictors of SF-6D. Abstinence and problematic use at follow-up were significant predictors of QWB-SA and SF-6D. Effect sizes ranged from 0.352 to 0.400 for abstinence and -0.484 to -0.585 for problematic use.
Generic preference-weighted health-related quality of life measures show moderate to good associations with substance-use specific measures and in certain circumstances can be used in their stead. This study provides further support for the use of the Quality of Well-Being scale and Medical Outcomes Study SF-12 in clinical and economic evaluations of substance use disorder interventions.
在物质使用障碍（SUD）患者样本中检验通用偏好加权健康相关生活质量测量的结构效度。
一项研究的纵向（基线和 6 个月随访）数据，该研究评估了改善 SUD 治疗衔接和参与的干预措施。
一个中央收治单位，将患者转介到美国中西部大都市区的七个 SUD 治疗中心。
共 495 名 SUD 患者。
参与者完成了两项偏好加权测量：自我管理的健康状况量表（QWB-SA）和标准赌博加权医疗结果研究 SF-12（SF-6D）。他们还接受了两项临床评估：成瘾严重程度指数（ASI）的所有七个领域和基于 DSM-IV 的症状清单。结构效度通过疾病特异性 SUD 和通用测量之间的关系来确定。
在未调整的分析中，QWB-SA 和 SF-6D 的变化分数与 ASI 六个亚量表变化分数显著相关，但与就业状况无关。在调整后的重复测量分析中，ASI 七个亚量表中的三个评分是 QWB-SA 的显著预测因素，5/7 ASI 亚量表评分是 SF-6D 的显著预测因素。随访时的 abstinence 和问题性使用是 QWB-SA 和 SF-6D 的显著预测因素。abstinence 的效应大小范围为 0.352 至 0.400，而问题性使用的效应大小范围为-0.484 至-0.585。
通用偏好加权健康相关生活质量测量与物质使用特异性测量具有中等至良好的关联，在某些情况下可以替代这些测量。本研究进一步支持在物质使用障碍干预的临床和经济评估中使用健康状况量表和医疗结果研究 SF-12。
