Martin-Puig Silvia, Wang Zhong, Chien Kenneth R
Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, 185 Cambridge Street, Boston, MA 02114-2790, USA.
Cell Stem Cell. 2008 Apr 10;2(4):320-31. doi: 10.1016/j.stem.2008.03.010.
Heart cells are the unitary elements that define cardiac function and disease. The recent identification of distinct families of cardiovascular progenitor cells begins to build a foundation for our understanding of the developmental logic of human cardiovascular disease, and also points to new approaches to arrest and/or reverse its progression, a major goal of regenerative medicine. In this review, we highlight recent clarifications, revisions, and advances in our understanding of the many lives of a heart cell, with a primary focus on the emerging links between cardiogenesis and heart stem cell biology.
心脏细胞是定义心脏功能和疾病的基本单位。最近对不同心血管祖细胞家族的鉴定，开始为我们理解人类心血管疾病的发育逻辑奠定基础，也为阻止和/或逆转其进展指出了新方法，这是再生医学的一个主要目标。在这篇综述中，我们着重介绍了我们对心脏细胞多种特性理解的最新澄清、修正和进展，主要关注心脏发生与心脏干细胞生物学之间新出现的联系。
