Martínez-Pérez L M, Cerda-Flores R M, Gallegos-Cabriales E C, Dávila-Rodríguez M I, Ibarra-Costilla E, Cortés-Gutiérrez E I
División de Genética, Centro de Investigación Biomédica del Noreste, Instituto Mexicano del Seguro Social, Monterrey, Mexico.
Prague Med Rep. 2007;108(3):248-55.
A case-control study was carried out on a sample of 15 Mexican patients (40-56 years old) with type 2 diabetes mellitus (DM2) that had developed five years and been treated with oral hypoglycemic drugs (sulfonylurea and/or metformin), with no microvascular or macrovascular complications. The aim of this study was to assess whether Mexican patients with DM2 differed from a control group in the frequency of micronuclei (MN). A control group of 10 individuals without DM2 (38-54 years old) was included. The frequency of MN in binucleated lymphocytes was analyzed according to the Fenech criteria. At time being this investigation should be considered as a preliminary study in which the influence of potential confounders cannot be adequately assessed. However, our result showed a MN frequency significant increase in DM2 patients (6.53 +/- 2.03 per 1000 cells) relative to that of the control group (3.10 +/- 1.79 per 1000 cells). MN may constitute a possible component of a panel of biomarkers for the risk of DM2. This cytogenetic damage also indicates an enhanced risk of cancer, as has been found in previous studies. These results should be validated by other researchers.
对15名墨西哥2型糖尿病（DM2）患者（40 - 56岁）进行了一项病例对照研究。这些患者患有DM2已达五年，一直使用口服降糖药（磺脲类和/或二甲双胍）治疗，且无微血管或大血管并发症。本研究的目的是评估患有DM2的墨西哥患者与对照组在微核（MN）频率上是否存在差异。纳入了一个由10名无DM2的个体（38 - 54岁）组成的对照组。根据Fenech标准分析双核淋巴细胞中的MN频率。目前，这项调查应被视为一项初步研究，其中潜在混杂因素的影响无法得到充分评估。然而，我们的结果显示，DM2患者的MN频率（每1000个细胞中6.53 +/- 2.03个）相对于对照组（每1000个细胞中3.10 +/- 1.79个）显著增加。MN可能构成DM2风险生物标志物组合的一个可能组成部分。这种细胞遗传学损伤也表明癌症风险增加，正如先前研究中所发现的那样。这些结果应由其他研究人员进行验证。
