Rostand Stephen G, Warnock David G
Division of Nephrology, University of Alabama at Birmingham, AL 35294, USA.
Clin J Am Soc Nephrol. 2008 Sep;3(5):1534. doi: 10.2215/CJN.01130308. Epub 2008 Apr 9.
A large body of work in diverse clinical and scientific areas has accumulated that supports a role for vitamin D in multiple organ systems and physiologic and molecular processes. The vitamin D receptor is distributed ubiquitously, and by binding with its receptor, vitamin D initiates a series of events that can affect cellular proliferation and differentiation, inflammation, the immune system, and the endocrine system, including the renin-angiotensin system, insulin resistance, and lipid metabolism.
在不同的临床和科学领域已经积累了大量的研究成果，这些成果支持维生素D在多个器官系统以及生理和分子过程中发挥作用。维生素D受体广泛分布，维生素D通过与其受体结合，引发一系列可影响细胞增殖与分化、炎症、免疫系统以及内分泌系统（包括肾素-血管紧张素系统、胰岛素抵抗和脂质代谢）的事件。
