Giménez Virna Margarita Martín, Sanz Raúl Lelio, Marón Feres José Mocayar, Ferder León, Manucha Walter
Instituto de Investigaciones en Ciencias Químicas, Facultad de Ciencias Químicas y Tecnológicas, Universidad Católica de Cuyo, San Juan, Argentina.
Área de Farmacología, Departamento de Patología, Facultad de Ciencias Médicas, Universidad Nacional de Cuyo, Argentina.
Curr Protein Pept Sci. 2020;21(10):948-954. doi: 10.2174/1389203721666200606220719.
The neuroinflammatory process is associated with the pathogenesis of many cardiovascular disorders, particularly with hypertension. In this regard, the deficiency of vitamin D seems to increase the risk of cardiovascular pathologies related to neuroinflammation. Long-term lack of vitamin D leads to over-activation of the renin-angiotensin-aldosterone system (RAAS), one of the essential mechanisms of blood pressure regulation.
This review summarizes the latest studies carried out to evaluate the primary mechanisms underlying the neuroprotective effect of vitamin D and its receptors (VDR) in the central nervous system. Besides, the present article condenses the evidence supporting the link between vitamin D and the RAAS in hypertension and neuroinflammation. Highlights Standpoints: Vitamin D deficiency is highly prevalent in the world, and the rising prevalence of neuroinflammatory diseases and associated pathologies such as hypertension around the world justifies the urgent need of searching new and more effective therapeutic methods that could be related to RAAS modulation and vitamin D levels management.
神经炎症过程与许多心血管疾病的发病机制相关，尤其是与高血压有关。在这方面，维生素D缺乏似乎会增加与神经炎症相关的心血管疾病风险。长期缺乏维生素D会导致肾素 - 血管紧张素 - 醛固酮系统（RAAS）过度激活，这是血压调节的重要机制之一。
本综述总结了为评估维生素D及其受体（VDR）在中枢神经系统中的神经保护作用的主要机制而开展的最新研究。此外，本文汇集了支持维生素D与高血压和神经炎症中的RAAS之间联系的证据。重点观点：维生素D缺乏在全球范围内高度普遍，全球神经炎症性疾病及相关病症（如高血压）患病率的上升证明了迫切需要寻找可能与RAAS调节和维生素D水平管理相关的新的更有效的治疗方法。
