Thongboonkerd Visith
Medical Proteomics Unit & Medical Molecular Biology Unit, Office for Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Contrib Nephrol. 2008;160:142-158. doi: 10.1159/000125972.
Kidney stone disease (nephrolithiasis) is an ancient and common affliction. It has been recognized for a long time with evidence of stone found in approximately 7,000-year-old mummies and remains a common problem worldwide, indicating ineffective prevention in the past. Precise pathogenic and molecular mechanisms of kidney stone formation are still poorly understood and should be further elucidated. Also, identification of novel therapeutic targets for better therapeutic outcome and successful prevention of the occurrence and recurrence of the stone are crucially required. One of the most promising tools for current and future biomedical research is proteomics, which has been extensively and widely applied to the nephrology field during the past 5 years. Its high-throughput capability holds a great promise also to kidney stone research. This chapter provides a brief overview of proteomic methodologies recently used for the investigation of nephrolithiasis and recent proteomic studies of nephrolithiasis are summarized.
肾结石病（肾石病）是一种古老且常见的疾病。长期以来它一直被人们所认识，在约7000年前的木乃伊中就发现了结石的证据，并且在全球范围内仍是一个常见问题，这表明过去的预防措施无效。肾结石形成的确切致病和分子机制仍知之甚少，需要进一步阐明。此外，至关重要的是要确定新的治疗靶点，以获得更好的治疗效果并成功预防结石的发生和复发。蛋白质组学是当前和未来生物医学研究中最有前景的工具之一，在过去5年中已广泛应用于肾脏病领域。其高通量能力对肾结石研究也有很大的前景。本章简要概述了最近用于研究肾石病的蛋白质组学方法，并总结了最近关于肾石病的蛋白质组学研究。
