丙型肝炎病毒（HCV）合并感染不影响HIV疾病中的TREC/IL-7途径。

HCV co-infection does not affect the TREC/IL-7 pathway in HIV disease.

作者信息

Cianci R, De Luca A, Cammarota G, Cauda R, Pandolfi F

出版信息

Eur Rev Med Pharmacol Sci. 2008 Jan-Feb;12(1):67-9.

PMID:18401975

Abstract

About thymic output, little is known in HIV-HCV co-infected patients. Thymic output can be measured by T-cell receptor excision circles (TREC) present in the so called "recent thymic emigrants" (RTEs). We have analyzed, by Real time PCR, sj-TREC+ cells in 11 patients with HIV-HCV co-infection; all patients were treated with highly active antiretroviral therapy (HAART), but were naive for interferon anti-HCV treatment. The results were compared with those of 21 age-matched normal donors. These data show no reduction of sj-TREC+ cells in co-infection. In 5 co-infected patients, IL-7 plasmatic levels were also evaluated by ELISA and no difference between co-infected patients and normal controls was found. Taken together, our data, although limited by the numerosity of the sample, may suggest that HCV co-infection does not affect the TREC/IL-7 pathway in HIV disease.

摘要

关于HIV-HCV合并感染患者的胸腺输出，目前所知甚少。胸腺输出可通过所谓“近期胸腺移植物”（RTEs）中存在的T细胞受体切除环（TREC）来测量。我们通过实时PCR分析了11例HIV-HCV合并感染患者的sj-TREC+细胞；所有患者均接受了高效抗逆转录病毒治疗（HAART），但未接受过干扰素抗HCV治疗。将结果与21名年龄匹配的正常供者的结果进行了比较。这些数据显示合并感染时sj-TREC+细胞没有减少。在5例合并感染患者中，还通过ELISA评估了IL-7血浆水平，发现合并感染患者与正常对照之间没有差异。综上所述，我们的数据虽然受样本数量限制，但可能提示HCV合并感染不影响HIV疾病中的TREC/IL-7途径。