艾滋病毒与丙型肝炎病毒合并感染与血浆白细胞介素-7水平降低有关。
HIV-hepatitis C virus co-infection is associated with decreased plasmatic IL-7 levels.
作者信息
Soriano-Sarabia Natalia, Vallejo Alejandro, Molina-Pinelo Sonia, Genebat Miguel, del Mar Rodríguez María, Sánchez-Quijano Armando, Martínez-Moya Manuel, Vivancos Jorge, Leal Manuel
机构信息
Viral Hepatitis and AIDS Unit, Spain.
出版信息
AIDS. 2007 Jan 11;21(2):253-5. doi: 10.1097/QAD.0b013e328011ec76.
We analysed the potential influence of hepatitis C virus (HCV) co-infection over IL-7 levels and thymic function in naive HIV-infected patients and after effective HAART. HIV-HCV-co-infected patients had lower plasmatic IL-7 levels compared with HIV-monoinfected patients. This effect may not be associated either with HCV monoinfection or with the rate of liver injury. These lower levels may explain, at least partly, the lower CD4 cell repopulation of HIV-HCV-co-infected patients after HAART.
我们分析了丙型肝炎病毒（HCV）合并感染对初治HIV感染患者及高效抗逆转录病毒治疗（HAART）有效后的IL-7水平和胸腺功能的潜在影响。与单纯HIV感染患者相比，HIV-HCV合并感染患者的血浆IL-7水平较低。这种效应可能既与HCV单独感染无关，也与肝损伤率无关。这些较低的水平可能至少部分解释了HIV-HCV合并感染患者在HAART后CD4细胞再增殖较低的原因。
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