Li Zheng-Hong, Dong Mei, Wang Zhi-Feng
Department of Pediatrics, PUMC Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.
World J Pediatr. 2008 Feb;4(1):45-8. doi: 10.1007/s12519-008-0009-7.
Constipation is a common disease in children. Despite many causes, constipation is most often functional. This study was undertaken to investigate the anorectal motility in children with functional constipation as compared with healthy children and to determine the efficacy of management based on the results of anorectal manometry.
A multi-functional manometry was used to detect the anorectal manometry indexes of 8 patients with functional constipation (11.4+/-4.8 years) as well as those of 10 healthy children (10.5+/-3.5 years) from May 2004 to June 2005. The patients received a combined treatment regimen including probiotics (bifid triple viable bacterial tablet), prebiotics (lactulose) and regular defecation according to the results of anorectal manometry. The efficacy of these conservative measures was estimated during the course of treatment.
No statistical difference was found in the indexes of effective length of the anal sphincter, anal tract maximal systolic pressure and the duration of more than 50% maximal systolic pressure between the two groups. But minimal sensitivity and maximal tolerated volume between the two groups were different significantly. Seven of the eight patients got better with the conservative treatment.
Abnormalities exist in the anorectal motility of the children with functional constipation. Conservative treatment regimen based on the results of anorectal manometry is significantly effective.
便秘是儿童常见疾病。尽管病因众多,但便秘最常见的是功能性的。本研究旨在调查功能性便秘儿童与健康儿童的肛门直肠动力,并根据肛门直肠测压结果确定治疗效果。
2004年5月至2005年6月,采用多功能测压法检测8例功能性便秘患儿(11.4±4.8岁)和10例健康儿童(10.5±3.5岁)的肛门直肠测压指标。根据肛门直肠测压结果,患者接受了包括益生菌(双歧三联活菌片)、益生元(乳果糖)和规律排便的联合治疗方案。在治疗过程中评估这些保守措施的疗效。
两组间肛门括约肌有效长度、肛管最大收缩压及最大收缩压持续时间超过50%的指标无统计学差异。但两组间最小敏感度和最大耐受量有显著差异。8例患者中有7例经保守治疗后病情好转。
功能性便秘儿童存在肛门直肠动力异常。基于肛门直肠测压结果的保守治疗方案显著有效。