Department of Psychiatry, Children's Hospital Boston, Boston, MA 02115 USA.
J Perinatol. 2011 Feb;31(2):130-6. doi: 10.1038/jp.2010.81. Epub 2010 Jul 22.
This study investigates the effectiveness of the Newborn Individualized Developmental Care and Assessment Program (NIDCAP) on neurobehavioral and electrophysiological functioning of preterm infants with severe intrauterine growth restriction (IUGR).
Thirty IUGR infants, 28 to 33 weeks gestational age, randomized to standard care (control/C=18), or NIDCAP (experimental/E=12), were assessed at 2 weeks corrected age (2wCA) and 9 months corrected age (9mCA) in regard to health, anthropometrics, and neurobehavior, and additionally at 2wCA in regard to electrophysiology (EEG).
The two groups were comparable in health and anthropometrics at 2wCA and 9mCA. The E-group at 2wCA showed significantly better autonomic, motor, and self-regulation functioning, improved motility, intensity and response thresholds, and reduced EEG connectivity among several adjacent brain regions. At 9mCA, the E-group showed significantly better mental performance.
This is the first study to show NIDCAP effectiveness for IUGR preterm infants.
本研究旨在探讨新生儿个体化发育护理和评估方案(NIDCAP)对严重宫内生长受限(IUGR)早产儿神经行为和电生理功能的影响。
将 30 名 28 至 33 孕周的 IUGR 婴儿随机分为标准护理组(对照组/C=18)或 NIDCAP 组(实验组/E=12),在纠正胎龄 2 周(2wCA)和 9 个月(9mCA)时评估其健康状况、人体测量学和神经行为,并在 2wCA 时评估电生理学(EEG)。
两组在 2wCA 和 9mCA 时的健康状况和人体测量学指标无显著差异。2wCA 时 E 组的自主神经、运动和自我调节功能显著更好,运动强度、反应阈值改善,几个相邻脑区的 EEG 连接减少。9mCA 时,E 组的精神表现显著更好。
这是第一项研究表明 NIDCAP 对 IUGR 早产儿有效。