York Adam W, Kirkland Stacey E, McCormick Charles L
Department of Polymer Science, The University of Southern Mississippi, Hattiesburg, MS 39406, USA.
Adv Drug Deliv Rev. 2008 Jun 10;60(9):1018-36. doi: 10.1016/j.addr.2008.02.006. Epub 2008 Feb 26.
Controlled/'living' radical polymerization methods, including the versatile reversible addition-fragmentation chain transfer (RAFT) polymerization process, are rapidly moving to the forefront in construction of drug and gene delivery vehicles. The RAFT technique allows an unprecedented latitude in the synthesis of water soluble or amphiphilic architectures with precise dimensions and appropriate functionality for attachment and targeted delivery of diagnostic and therapeutic agents. This review focuses on the chemistry of the RAFT process and its potential for preparing well-defined block copolymers and conjugates capable of stimuli-responsive assembly and release of bioactive agents in the physiological environment. Recent examples of block copolymers with designed structures and segmental compositions responsive to changes in pH or temperature are reviewed and hurdles facing further development of these novel systems are discussed.
可控/“活性”自由基聚合方法，包括用途广泛的可逆加成-断裂链转移（RAFT）聚合过程，正在迅速成为构建药物和基因递送载体的前沿技术。RAFT技术在合成具有精确尺寸以及适合诊断和治疗剂附着与靶向递送功能的水溶性或两亲性结构方面，提供了前所未有的自由度。本综述聚焦于RAFT过程的化学原理及其在制备能够在生理环境中进行刺激响应组装和生物活性剂释放的结构明确的嵌段共聚物和缀合物方面的潜力。本文综述了具有响应pH值或温度变化的设计结构和链段组成的嵌段共聚物的近期实例，并讨论了这些新型体系进一步发展所面临的障碍。
