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水性介质中的双响应性两亲性聚（甲基丙烯酸二甲氨基乙酯 - 甲基丙烯酸月桂酯 - 甲基丙烯酸寡聚乙二醇酯）三元共聚物纳米组装体

Dual-Responsive Amphiphilic P(DMAEMA-co-LMA-co-OEGMA) Terpolymer Nano-Assemblies in Aqueous Media.

作者信息

Tomara Maria, Selianitis Dimitrios, Pispas Stergios

机构信息

Theoretical and Physical Chemistry Institute, National Hellenic Research Foundation, 48 Vassileos Constantinou Avenue, 11635 Athens, Greece.

出版信息

Nanomaterials (Basel). 2022 Oct 27;12(21):3791. doi: 10.3390/nano12213791.

DOI:10.3390/nano12213791
PMID:36364568
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9659099/
Abstract

This work reports on the synthesis and self-assembly of a novel series of dual-responsive poly[2-(dimethylamino)ethylmethacrylate-co-laurylmethacrylate-co-(oligoethyleneglycol)methacrylate], P(DMAEMA-co-LMA-co-OEGMA)statistical terpolymers in aqueous solutions. Five P(DMAEMA-co-LMA-co-OEGMA) amphiphilic terpolymers, having different content of the three monomers, were synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization. The success of the synthesis was confirmed by the molecular characterization of the terpolymers via size exclusion chromatography (SEC) for the determination of molecular weights and the molecular weight distributions. By using nuclear magnetic resonance (H-NMR) and Fourier-transform infrared (FTIR) spectroscopy, it was possible to determine the exact composition of the terpolymers. Dynamic light scattering (DLS) and fluorescence spectroscopy (FS) indicated the formation of P(DMAEMA-co-LMA-co-OEGMA) unimolecular or multichain aggregates in aqueous solutions, as a response to pH, temperature and ionic strength changes, with their dimensions being largely affected. The amphiphilic terpolymers were able to encapsulate the hydrophobic drug curcumin (CUR) and demonstrate stability to fetal bovine serum (FBS) solutions. These terpolymer aggregates were studied by DLS, FS and UV-Vis, and it was found that they may have been used as potential nanocarriers for drug delivery and bio-imaging applications.

摘要

本文报道了一系列新型的双响应性聚[甲基丙烯酸2-(二甲氨基)乙酯-共-甲基丙烯酸月桂酯-共-(聚乙二醇)甲基丙烯酸酯]，即P(DMAEMA-co-LMA-co-OEGMA)统计三元共聚物在水溶液中的合成与自组装。通过可逆加成-断裂链转移(RAFT)聚合反应合成了五种具有不同单体含量的P(DMAEMA-co-LMA-co-OEGMA)两亲性三元共聚物。通过尺寸排阻色谱(SEC)对三元共聚物进行分子量和分子量分布测定的分子表征，证实了合成的成功。利用核磁共振(H-NMR)和傅里叶变换红外(FTIR)光谱，可以确定三元共聚物的确切组成。动态光散射(DLS)和荧光光谱(FS)表明，作为对pH、温度和离子强度变化的响应，P(DMAEMA-co-LMA-co-OEGMA)在水溶液中形成单分子或多链聚集体，其尺寸受到很大影响。两亲性三元共聚物能够包封疏水性药物姜黄素(CUR)，并对胎牛血清(FBS)溶液表现出稳定性。通过DLS、FS和紫外可见光谱对这些三元共聚物聚集体进行了研究，发现它们可能用作药物递送和生物成像应用的潜在纳米载体。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53e8/9659099/895faacd3dfe/nanomaterials-12-03791-g012.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53e8/9659099/e4989074d03f/nanomaterials-12-03791-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53e8/9659099/83059d242b19/nanomaterials-12-03791-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53e8/9659099/0313d44e83c8/nanomaterials-12-03791-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53e8/9659099/e6a05bb9b72d/nanomaterials-12-03791-g009.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53e8/9659099/895faacd3dfe/nanomaterials-12-03791-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53e8/9659099/d33dd3cb59a2/nanomaterials-12-03791-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53e8/9659099/0394c9913d2d/nanomaterials-12-03791-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53e8/9659099/7394a34c5c8c/nanomaterials-12-03791-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53e8/9659099/f6acbb640967/nanomaterials-12-03791-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53e8/9659099/9d0bfa02bc07/nanomaterials-12-03791-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53e8/9659099/50defa54a72c/nanomaterials-12-03791-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53e8/9659099/e4989074d03f/nanomaterials-12-03791-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53e8/9659099/83059d242b19/nanomaterials-12-03791-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53e8/9659099/0313d44e83c8/nanomaterials-12-03791-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53e8/9659099/e6a05bb9b72d/nanomaterials-12-03791-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53e8/9659099/fdfee98c0a1d/nanomaterials-12-03791-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53e8/9659099/c242a7e1affe/nanomaterials-12-03791-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53e8/9659099/895faacd3dfe/nanomaterials-12-03791-g012.jpg

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