Martinez A, Pailhoux E, Jean C
CNRS URA 360, Université Blaise Pascal, Aubière, France.
Mol Cell Endocrinol. 1991 Apr;76(1-3):191-200. doi: 10.1016/0303-7207(91)90273-u.
The mRNA encoding a major protein of the mouse vas deferens (MVDP) was first detected in 10-day-old males and its concentration increased sharply between 10 and 20 days, reaching adult levels at 40 days. This increase was not associated with an increase in tissular androgen concentrations. In 30-day-old mice castrated at birth or treated with cyproterone acetate over 29 days, MVDP mRNA levels were not abolished and were similar to those measured in 10- and 20-day-old controls. These results suggest that the neonatal expression of MVDP gene is independent of androgens. In addition, precocious accumulation of MVDP mRNA could be induced by injection of excess amounts of androgens in 20- but not in 10-day-old animals. The prepubertal increase in MVDP mRNA levels is androgen-dependent but other factors may be necessary for MVDP expression.
编码小鼠输精管主要蛋白质（MVDP）的信使核糖核酸（mRNA）首次在10日龄雄性小鼠中被检测到，其浓度在10至20天之间急剧增加，在40天时达到成年水平。这种增加与组织雄激素浓度的增加无关。在出生时阉割或经醋酸环丙孕酮处理29天的30日龄小鼠中，MVDP mRNA水平并未消失，且与在10日龄和20日龄对照小鼠中测得的水平相似。这些结果表明，MVDP基因的新生儿期表达独立于雄激素。此外，在20日龄而非10日龄动物中注射过量雄激素可诱导MVDP mRNA过早积累。MVDP mRNA水平在青春期前的增加依赖于雄激素，但MVDP的表达可能还需要其他因素。
