Guney Engin, Kisakol Gurcan, Ozgen A Gokhan, Yilmaz Candeger, Kabalak Taylan
Department of Endocrinology, Medical Faculty of Adnan Menderes University, Aydin, Turkey.
Neuro Endocrinol Lett. 2008 Apr;29(2):252-5.
Bisphosphonates are widely used for the treatment of metabolic bone disorders and their effects on lipid metabolism have also been investigated. Some studies reported that bisphosphonates have beneficial effects on serum cholesterol levels. In this study we aimed to assess the effects of bisphosphonates on lipid levels in hyperlipidemic patients who received bisphosphonates because of osteoporosis.
49 female patients (age: 54.2+/-7.2 years) with diagnosis of osteoporosis and hyperlipidemia were enrolled. Patients received alendronate 10 mg/day and they were followed up for 6 months. Pretreatment total cholesterol, triglyceride, HDL-cholesterol, LDL-cholesterol, apolipoprotein A1 and apolipoprotein B levels were measured and compared with post-treatment levels.
Pretreatment and post-treatment levels of total cholesterol were 255.2+/-34.3; 233.02+/-37.0 mg/dL, triglyceride levels were 153.0+/-57.3; 129.1+/-54.4 mg/dL, and LDL levels were 170.7+/-30.5; 160.0+/-34.2 mg/dL, respectively. Reductions in total cholesterol, triglyceride and LDL-cholesterol levels were statistically significant; whereas differences in HDL-cholesterol, apolipoprotein-A1 and apolipoprotein-B levels were not significant.
Data from our study suggest that alendronate therapy may have beneficial effects on lipid metabolism. Thus, when hyperlipidemia is detected in patients receiving bisphosphonates, it is considered reasonable to follow the patient for a while before initiating antihyperlipidemic agent to prevent unnecessary use of drugs.
双膦酸盐被广泛用于治疗代谢性骨病，其对脂质代谢的影响也已得到研究。一些研究报告称双膦酸盐对血清胆固醇水平有有益作用。在本研究中，我们旨在评估双膦酸盐对因骨质疏松而接受双膦酸盐治疗的高脂血症患者脂质水平的影响。
纳入49例诊断为骨质疏松和高脂血症的女性患者（年龄：54.2±7.2岁）。患者接受阿仑膦酸钠10毫克/天的治疗，并随访6个月。测量治疗前的总胆固醇、甘油三酯、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、载脂蛋白A1和载脂蛋白B水平，并与治疗后的水平进行比较。
总胆固醇的治疗前和治疗后水平分别为255.2±34.3；233.02±37.0毫克/分升，甘油三酯水平分别为153.0±57.3；129.1±54.4毫克/分升，低密度脂蛋白水平分别为170.7±30.5；160.0±34.2毫克/分升。总胆固醇、甘油三酯和低密度脂蛋白胆固醇水平的降低具有统计学意义；而高密度脂蛋白胆固醇、载脂蛋白-A1和载脂蛋白-B水平的差异不显著。
我们研究的数据表明阿仑膦酸钠治疗可能对脂质代谢有有益作用。因此，当在接受双膦酸盐治疗的患者中检测到高脂血症时，在开始使用抗高脂血症药物之前先对患者进行一段时间的随访被认为是合理的，以避免不必要的药物使用。
