Leyden James
Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
J Drugs Dermatol. 2008 Feb;7(2 Suppl):s8-11.
Benzoyl peroxide (BPO) has been an important component of the acne treatment armamentarium for decades. A number of characteristics contribute to its success in acne, including its lipophilicity, potent antibacterial activity, and ability to suppress antibiotic-resistant strains of Propionibacterium acnes. With some commercially available products in which BPO comprises crystals in suspension, aggregation of BPO can occur on the skin surface in large clumps, resulting in poor penetration of sebaceous follicles. In addition, the poor water solubility of BPO, coupled with its chemical instability in other solvents, presents challenges with respect to formulating topical products with optimal bioavailability, stability, and tolerability. Several products and vehicle systems have evolved in attempts to improve on the benefits of BPO in treating acne. A new acne treatment has been developed that contains 5% solubilized BPO consisting of small-size particles. This new product exhibits enhanced follicular penetration of BPO, improved P acnes kill rates and clinical efficacy, and good consumer acceptance relative to existing formulations.
几十年来，过氧化苯甲酰（BPO）一直是痤疮治疗药物库中的重要成分。它在痤疮治疗中取得成功有多个因素，包括其亲脂性、强大的抗菌活性以及抑制痤疮丙酸杆菌耐药菌株的能力。在一些市售产品中，BPO以悬浮晶体形式存在，BPO可能会在皮肤表面大量聚集形成团块，导致皮脂腺毛囊的渗透不佳。此外，BPO的水溶性差，加上其在其他溶剂中的化学不稳定性，给配制具有最佳生物利用度、稳定性和耐受性的局部用产品带来了挑战。为了提高BPO治疗痤疮的益处，已经开发了几种产品和载体系统。一种新的痤疮治疗产品已经研制出来，它含有5%由小颗粒组成的可溶解BPO。相对于现有配方，这种新产品显示出BPO在毛囊中的渗透增强、痤疮丙酸杆菌杀灭率提高和临床疗效改善，并且消费者接受度良好。
