Paliwal Sumit, Mitragotri Samir
Department of Chemical Engineering, University of California, Santa Barbara, CA 93106, USA.
Ultrasonics. 2008 Aug;48(4):271-8. doi: 10.1016/j.ultras.2008.02.002. Epub 2008 Mar 7.
The therapeutic benefits of several existing ultrasound-based therapies such as facilitated drug delivery, tumor ablation and thrombolysis derive largely from physical or mechanical effects. In contrast, ultrasound can also trigger various time-dependent biochemical responses in the exposed biological milieu. Several biological responses to ultrasound exposure have been previously described in the literature but only a handful of these provide therapeutic opportunities. These include the use of ultrasound for healing of soft tissues and bones, the use of ultrasound for inducing non-necrotic tumor atrophy as well as for potentiation of chemotherapeutic drugs, activation of the immune system, angiogenesis and suppression of phagocytosis. A review of these therapeutic opportunities is presented with particular emphasis on their mechanisms. Overall, this review presents the increasing importance of ultrasound's role as a biological sensitizer enabling novel therapeutic strategies.
几种现有的基于超声的疗法，如促进药物递送、肿瘤消融和溶栓，其治疗益处很大程度上源于物理或机械效应。相比之下，超声还可在暴露的生物环境中引发各种时间依赖性的生化反应。先前文献中已描述了对超声暴露的几种生物学反应，但其中只有少数能提供治疗机会。这些包括利用超声促进软组织和骨骼愈合、利用超声诱导非坏死性肿瘤萎缩以及增强化疗药物疗效、激活免疫系统、促进血管生成和抑制吞噬作用。本文对这些治疗机会进行了综述，特别强调了其机制。总体而言，本综述表明超声作为一种生物敏化剂在实现新型治疗策略方面的作用日益重要。
