Sun Qi, Li Chao-Hua, Liu Qi-Shun, Zhang Yuan-Bin, Hu Bai-Song, Feng Qi, Lang Yong
Department of Orthopedics, Hangzhou Fuyang Hospital of Orthopedics of Traditional Chinese Medicine, Hangzhou, 311499, China.
Department of Orthopedics, Zhejiang Medical & Health Group Hangzhou Hospital, Hangzhou, 310015, China.
Regen Ther. 2025 Feb 13;28:544-557. doi: 10.1016/j.reth.2025.01.025. eCollection 2025 Mar.
Bone defects repair continues to be a significant challenge facing the world. Biological scaffolds, bioactive molecules, and cells are the three major elements of bone tissue engineering, which have been widely used in bone regeneration therapy, especially with the rise of bioactive molecules in recent years. According to their physical properties, they can be divided into force, magnetic field (MF), electric field (EF), ultrasonic wave, light, heat, etc. However, the transmission of bioactive molecules has obvious shortcomings that hinder the development of the tissue-rearing process. This paper reviews the mechanism of physical signal induction in bone tissue engineering in recent years. It summarizes the application strategies of physical signal in bone tissue engineering, including biomaterial designs, physical signal loading strategies and related pathways. Finally, the ongoing challenges and prospects for the future are discussed.
骨缺损修复仍然是世界面临的一项重大挑战。生物支架、生物活性分子和细胞是骨组织工程的三大要素，已广泛应用于骨再生治疗，尤其是近年来随着生物活性分子的兴起。根据其物理性质，它们可分为力、磁场（MF）、电场（EF）、超声波、光、热等。然而，生物活性分子的传递存在明显缺点，阻碍了组织培养过程的发展。本文综述了近年来骨组织工程中物理信号诱导的机制。总结了物理信号在骨组织工程中的应用策略，包括生物材料设计、物理信号加载策略及相关途径。最后，讨论了当前面临的挑战和未来的前景。
