Mistretta V I, Delanaye P, Chapelle J-P, Souberbielle J-C, Cavalier E
Service de chimie médicale, CHU de Liège, université de Liège, domaine du Sart-Tilman, Liège, Belgique.
Rev Med Interne. 2008 Oct;29(10):815-20. doi: 10.1016/j.revmed.2008.03.003. Epub 2008 Apr 11.
Nearly one billion people around the world are deficient in vitamin D and need to be supplemented. Vitamin D is available in medicines and fortified foods. It is available in two forms: vitamin D2 (ergocalciferol) and vitamin D3 (cholecalciferol).
The pharmacopeiae consider these steroid hormones as equivalent and interchangeable. However, several studies have showed that serum level of 25(OH)D is increased more effectively with vitamin D3 than vitamin D2. Vitamin D2 has shorter plasma half-life and a lower affinity for the vitamin D binding protein, the hepatic vitamin D hydroxylase and the vitamin D receptor.
Vitamin D2 should not be regarded anymore as suitable for supplementation or fortification. Currently though, it is still the most used in some countries such as Portugal and Australia.
全球近十亿人缺乏维生素D，需要进行补充。维生素D存在于药物和强化食品中。它有两种形式：维生素D2（麦角钙化醇）和维生素D3（胆钙化醇）。
药典认为这些类固醇激素是等效且可互换的。然而，多项研究表明，维生素D3比维生素D2能更有效地提高血清25(OH)D水平。维生素D2的血浆半衰期较短，对维生素D结合蛋白、肝脏维生素D羟化酶和维生素D受体的亲和力较低。
不应再认为维生素D2适合用于补充或强化。不过目前在葡萄牙和澳大利亚等一些国家，它仍是使用最广泛的。
